caa a22 4500 445824611 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00246-010-9881-8 doi (NATIONALLICENCE)springer-10.1007/s00246-010-9881-8 Role of Caveolae in Cardiac Protection [Elektronische Daten] [David Roth, Hemal Patel] Myocardial ischemia/reperfusion injury is a major cause of morbidity and mortality. The molecular signaling pathways involved in cardiac protection from myocardial ischemia/reperfusion injury are complex. An emerging idea in signal transduction suggests the existence of spatially organized complexes of signaling molecules in lipid-rich microdomains of the plasma membrane known as caveolae. Caveolins—proteins abundant in caveolae—provide a scaffold to organize, traffic, and regulate signaling molecules. Numerous signaling molecules involved in cardiac protection are known to exist within caveolae or interact directly with caveolins. Over the last 4years, our laboratories have explored the hypothesis that caveolae are vitally important to cardiac protection from myocardial ischemia/reperfusion injury. We have provided evidence that (1) caveolae and the caveolin isoforms 1 and 3 are essential for cardiac protection from myocardial ischemia/reperfusion injury, (2) stimuli that produce preconditioning of cardiac myocytes, including brief periods of ischemia/reperfusion and exposure to volatile anesthetics, alter the number of membrane caveolae, and (3) cardiac myocyte-specific overexpression of caveolin-3 can produce innate cardiac protection from myocardial ischemia/reperfusion injury. The work demonstrates that caveolae and caveolins are critical elements of signaling pathways involved in cardiac protection and suggests that caveolins are unique targets for therapy in patients at risk of myocardial ischemia. The Author(s), 2011 Caveolae nationallicence Ischemia/reperfusion injury nationallicence Cardiac protection nationallicence Roth David VA Medical Center (125), Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, 92161-5085, San Diego, CA, USA aut Patel Hemal VA Medical Center (125), Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, 92161-5085, San Diego, CA, USA aut Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 329-333 0172-0643 32:3<329 2011 32 246 https://doi.org/10.1007/s00246-010-9881-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9881-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roth David VA Medical Center (125), Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, 92161-5085, San Diego, CA, USA aut NATIONALLICENCE 700 1- Patel Hemal VA Medical Center (125), Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, 92161-5085, San Diego, CA, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 329-333 0172-0643 32:3<329 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer