caa a22 4500 445824638 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00246-010-9880-9 doi (NATIONALLICENCE)springer-10.1007/s00246-010-9880-9 Baines Christopher Department of Biomedical Sciences, Dalton Cardiovascular Research Center, University of Missouri-Columbia, 134 Research Park Drive, 65211, Columbia, MO, USA aut The Mitochondrial Permeability Transition Pore and the Cardiac Necrotic Program [Elektronische Daten] [Christopher Baines] That apoptosis is mediated by specific pathways has long been established. However, more recent data have begun to suggest that necrosis may in fact be "programmed” and not a default "accidental” pathway as previously thought. The mitochondrial permeability transition pore, a known contributor to the development of many cardiac diseases, is emerging as one among several mediators of this necrotic program. Consequently, this report briefly reviews the roles of necrosis versus apoptosis in the pathogenesis of cardiac disease and discusses the role that the mitochondrial pore plays in cardiac necrotic cell death. Springer Science+Business Media, LLC, 2010 Apoptosis nationallicence Calpain nationallicence Cyclophilin-D nationallicence Mitochondria nationallicence Necrosis nationallicence PARP nationallicence Permeability transition nationallicence Reactive oxygen species nationallicence RIP kinases nationallicence Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 258-262 0172-0643 32:3<258 2011 32 246 https://doi.org/10.1007/s00246-010-9880-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9880-9 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Baines Christopher Department of Biomedical Sciences, Dalton Cardiovascular Research Center, University of Missouri-Columbia, 134 Research Park Drive, 65211, Columbia, MO, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 258-262 0172-0643 32:3<258 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer