caa a22 4500 445824662 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00246-011-9893-z doi (NATIONALLICENCE)springer-10.1007/s00246-011-9893-z Epigenetic Regulation of E2F-1-Dependent Bnip3 Transcription and Cell Death by Nuclear Factor-κB and Histone Deacetylase-1 [Elektronische Daten] [Hongying Gang, Rimpy Dhingra, Yan Wang, Wajihah Mughal, Joseph Gordon, Lorrie Kirshenbaum] A delicate balance exists between cell growth and cell death. In the context of the adult myocardium, inappropriate or inordinate cell loss through an apoptotic process may profoundly influence cardiac structure, function, or both given the limited and meager ability of the heart for repair after injury. Earlier work by the authors' laboratory identified a close relation between cell cycle factor E2F-1 and hypoxia-inducible factor Bnip3 as the key regulator of apoptosis and autophagy in ventricular myocytes. Epigenetic changes by histone-modifying proteins, namely, histone deacetylases (HDACs) influence cell survival by altering the activity of histone core proteins, transcription factors, or both. This report highlights the intricate nature between the cellular factors E2F-1 and nuclear factor-κB (NF-κB) and the epigenetic regulation of Bnip3 gene transcription by HDAC1 for cell survival of ventricular myocytes. Springer Science+Business Media, LLC, 2011 Apoptosis nationallicence Bnip3 nationallicence E2F-1 nationallicence Histone deacetylases nationallicence Mitochondrion nationallicence NF-κB nationallicence Gang Hongying Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut Dhingra Rimpy Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut Wang Yan Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut Mughal Wajihah Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut Gordon Joseph Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut Kirshenbaum Lorrie Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 263-266 0172-0643 32:3<263 2011 32 246 https://doi.org/10.1007/s00246-011-9893-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9893-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gang Hongying Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Dhingra Rimpy Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Wang Yan Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Mughal Wajihah Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Gordon Joseph Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Kirshenbaum Lorrie Department of Physiology, Faculty of Medicine, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, MB, Canada aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 263-266 0172-0643 32:3<263 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer