caa a22 4500 445824727 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00246-010-9855-x doi (NATIONALLICENCE)springer-10.1007/s00246-010-9855-x Is Autophagy in Response to Ischemia and Reperfusion Protective or Detrimental for the Heart? [Elektronische Daten] [Sebastiano Sciarretta, Nirmala Hariharan, Yoshiya Monden, Daniela Zablocki, Junichi Sadoshima] Autophagy is a catabolic process that degrades long-lived proteins and damaged organelles by sequestering them into double membrane structures termed "autophagosomes” and fusing them with lysosomes. Autophagy is active in the heart at baseline and further stimulated under stress conditions including starvation, ischemia/reperfusion, and heart failure. It plays an adaptive role in the heart at baseline, thereby maintaining cardiac structure and function and inhibiting age-related cardiac abnormalities. Autophagy is activated by ischemia and nutrient starvation in the heart through Sirt1-FoxO- and adenosine monophosphate (AMP)-activated protein kinase (AMPK)-dependent mechanisms, respectively. Activation of autophagy during ischemia is essential for cell survival and maintenance of cardiac function. Autophagy is strongly activated in the heart during reperfusion after ischemia. Activation of autophagy during reperfusion could be either protective or detrimental, depending on the experimental model. However, strong induction of autophagy accompanied by robust upregulation of Beclin1 could cause autophagic cell death, thereby proving to be detrimental. This review provides an overview regarding both protective and detrimental functions of autophagy in the heart and discusses possible applications of current knowledge to the treatment of heart disease. Springer Science+Business Media, LLC, 2010 Autophagy nationallicence Beclin1 nationallicence Ischemia/reperfusion nationallicence Sciarretta Sebastiano Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, 07103, Newark, NJ, USA aut Hariharan Nirmala Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, 07103, Newark, NJ, USA aut Monden Yoshiya Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, 07103, Newark, NJ, USA aut Zablocki Daniela Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, 07103, Newark, NJ, USA aut Sadoshima Junichi Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, 07103, Newark, NJ, USA aut Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 275-281 0172-0643 32:3<275 2011 32 246 https://doi.org/10.1007/s00246-010-9855-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9855-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sciarretta Sebastiano Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, 07103, Newark, NJ, USA aut NATIONALLICENCE 700 1- Hariharan Nirmala Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, 07103, Newark, NJ, USA aut NATIONALLICENCE 700 1- Monden Yoshiya Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, 07103, Newark, NJ, USA aut NATIONALLICENCE 700 1- Zablocki Daniela Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, 07103, Newark, NJ, USA aut NATIONALLICENCE 700 1- Sadoshima Junichi Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, 07103, Newark, NJ, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 275-281 0172-0643 32:3<275 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer