caa a22 4500 445824735 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00246-011-9894-y doi (NATIONALLICENCE)springer-10.1007/s00246-011-9894-y Cardiomyocyte Death: Insights from Molecular and Microstructural Magnetic Resonance Imaging [Elektronische Daten] [Natalia Berry, David Sosnovik] Cardiomyocytes can die via necrosis, apoptosis, and autophagy. Although the molecular signals and pathways underlying these processes have been well elucidated, the pathophysiology of cardiomyocyte death remains incompletely understood. This review describes the development and application of novel imaging techniques to detect and characterize cardiomyocyte death noninvasively in vivo. It focuses on molecular and microstructural magnetic resonance images (MRIs) and their respective abilities to image cellular events such as apoptosis, inflammation, and myofiber architecture. These in vivo imaging techniques have the potential to provide novel insights into the mechanisms of cardiomyocyte death and to help guide the development of novel cardioprotective therapies. Springer Science+Business Media, LLC, 2011 Apoptosis nationallicence Diffusion nationallicence Molecular imaging nationallicence MRI nationallicence Myocardium nationallicence Necrosis nationallicence Berry Natalia Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 5404, 149 13th Street, 02129, Charlestown, MA, USA aut Sosnovik David Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 5404, 149 13th Street, 02129, Charlestown, MA, USA aut Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 290-296 0172-0643 32:3<290 2011 32 246 https://doi.org/10.1007/s00246-011-9894-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9894-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berry Natalia Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 5404, 149 13th Street, 02129, Charlestown, MA, USA aut NATIONALLICENCE 700 1- Sosnovik David Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 5404, 149 13th Street, 02129, Charlestown, MA, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 290-296 0172-0643 32:3<290 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer