caa a22 4500 445824743 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00246-011-9888-9 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9888-9 Engineered Human Cardiac Tissue [Elektronische Daten] [Kareen Kreutziger, Charles Murry] The human heart is the first organ to develop during embryogenesis and is arguably the most essential organ for life. However, after birth, the heart has very little capacity to repair malformations such as congenital heart defects or to regenerate after an injury such as myocardial infarction. Cardiac tissue engineering addresses the need for a therapeutic biologic implant to restore cardiac structure and muscle mass. This review highlights current research in cardiac tissue engineering that uses human cardiomyocytes derived from embryonic stem cells. Other human cell sources are discussed because future human therapies will benefit from novel techniques using human-induced pluripotent stem cells and cardiomyocytes derived from direct reprogramming of somatic cells. Furthermore, this review examines the main approaches to creating engineered cardiac tissue with synthetic scaffolds, natural scaffolds, or no exogenous scaffold (i.e., "scaffold free”). The choice of scaffold and cells ultimately depends on the goals of the therapy, so the review considers how congenital heart defects define the design parameters for cardiac tissue engineering needed for surgical repair in pediatric cardiac patients. Springer Science+Business Media, LLC, 2011 Cardiac tissue engineering nationallicence Human cardiomyocytes nationallicence Pluripotent stem cells nationallicence Therapeutic biologic implant nationallicence Kreutziger Kareen Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 815 Mercer Street, Brotman 454, Box 358050, 98109, Seattle, WA, USA aut Murry Charles Department of Pathology, University of Washington, Box 357470, 98195, Seattle, WA, USA aut Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 334-341 0172-0643 32:3<334 2011 32 246 https://doi.org/10.1007/s00246-011-9888-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9888-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kreutziger Kareen Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 815 Mercer Street, Brotman 454, Box 358050, 98109, Seattle, WA, USA aut NATIONALLICENCE 700 1- Murry Charles Department of Pathology, University of Washington, Box 357470, 98195, Seattle, WA, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 334-341 0172-0643 32:3<334 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer