caa a22 4500 445824751 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00246-011-9920-0 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9920-0 Rho-Kinase in Development and Heart Failure: Insights From Genetic Models [Elektronische Daten] [Jianjian Shi, Lumin Zhang, Lei Wei] Rho-kinase (ROCK) belongs to the AGC (protein kinase A/protein kinase G/protein kinase C, PKA/PKG/PKC) family of serine/threonine kinases and is a major downstream effector of small GTPase RhoA. Rho-kinase is involved in a wide range of fundamental cellular functions such as contraction, adhesion, migration, and proliferation. Two ROCK isoforms, ROCK1 and ROCK2, are assumed to be functionally redundant, based largely on the major common activators, the high degree of homology within the kinase domain, and studies from overexpression with kinase constructs and chemical inhibitors (e.g., Y27632 and fasudil), which inhibit both ROCK1 and ROCK2. Gene targeting and RNA interference approaches allow further dissection of distinct cellular, physiologic, and pathophysiologic functions of the two ROCK isoforms. This review focuses on the current understanding of ROCK isoform biology, with a particular emphasis on their functions in mouse development and the pathogenesis of heart failure. Springer Science+Business Media, LLC, 2011 Genetic models nationallicence Heart failure nationallicence Rho-kinase nationallicence ROCK nationallicence Shi Jianjian Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University, School of Medicine, 1044 West Walnut Street, 46202-5225, Indianapolis, IN, USA aut Zhang Lumin Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University, School of Medicine, 1044 West Walnut Street, 46202-5225, Indianapolis, IN, USA aut Wei Lei Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University, School of Medicine, 1044 West Walnut Street, 46202-5225, Indianapolis, IN, USA aut Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 297-304 0172-0643 32:3<297 2011 32 246 https://doi.org/10.1007/s00246-011-9920-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9920-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shi Jianjian Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University, School of Medicine, 1044 West Walnut Street, 46202-5225, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Zhang Lumin Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University, School of Medicine, 1044 West Walnut Street, 46202-5225, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Wei Lei Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University, School of Medicine, 1044 West Walnut Street, 46202-5225, Indianapolis, IN, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 297-304 0172-0643 32:3<297 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer