caa a22 4500 445824778 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00246-010-9883-6 doi (NATIONALLICENCE)springer-10.1007/s00246-010-9883-6 Hill Joseph Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, NB11.200, 6000 Harry Hines Blvd, 75390-8573, Dallas, TX, USA aut Autophagy in Cardiac Plasticity and Disease [Elektronische Daten] [Joseph Hill] The heart is a highly plastic organ. In response to the physiological stress of normal life, as well as the pathological stress of disease, the myocardium manifests robust and rapid changes in mass. In the context of disease-associated stress, this myocardial remodeling response can culminate in ventricular thinning, mechanical dysfunction, and a clinical syndrome of heart failure. Recently, autophagy, a process of cellular cannibalization, has been implicated in many of these remodeling reactions. In some settings, the autophagic response is beneficial and pro-survival; in other contexts, it is maladaptive and promotes disease progression. Together, these observations raise the intriguing prospect of targeting maladaptive autophagy and advancing cell survival-promoting, adaptive autophagy to benefit patients with heart disease. Springer Science+Business Media, LLC, 2011 Hypertrophy nationallicence Heart failure nationallicence Autophagy nationallicence Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 282-289 0172-0643 32:3<282 2011 32 246 https://doi.org/10.1007/s00246-010-9883-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9883-6 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hill Joseph Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, NB11.200, 6000 Harry Hines Blvd, 75390-8573, Dallas, TX, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/3(2011-03-01), 282-289 0172-0643 32:3<282 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer