caa a22 4500 445824808 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00246-011-9901-3 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9901-3 Red Blood Cell Transfusion for Infants With Single-Ventricle Physiology [Elektronische Daten] [James Kuo, Kevin Maher, Paul Kirshbom, William Mahle] The purpose of this study was to assess how red blood cell (RBC) transfusions impact hemodynamic parameters in infants with single-ventricle lesions. This was a retrospective chart review. The setting was a pediatric cardiac intensive care unit at a tertiary care children's hospital. Fifty-nine patients <1year of age with single-ventricle physiology who received a blood transfusion between December 2007 and April 2009 were analyzed. They received a total of 183 transfusions. Exclusion criteria included transfusions given within 72h of cardiac surgery or transfusions given to patients with active bleeding. There were no interventions. The study population was divided into terciles based on pretransfusion hemoglobin (Hgb) concentration. The pretransfusion Hgb concentration in group A was 7.8 to 12.3gm/dl, in group B was 12.4 to 13.2 gm/dl, and in group C was 13.3 to 15.7gm/dl. Heart rate, blood pressure, arterial saturation, and cerebral near-infrared spectroscopy (cNIRS) values before transfusion, as well as at 1, 2, 4, 8, and 12h after transfusion, were collected. There was significant improvement in diastolic blood pressure, arterial saturation, and cNIRS in group A after 12h. Transfusions given in group B also resulted in improvement in diastolic blood pressure and arterial saturation, with less robust response of cNIRS. In group C, only arterial saturation values increased significantly. RBC transfusions can improve hemodynamics and markers of oxygen delivery in infants with single-ventricle physiology, but further studies are needed to determine an optimal Hgb level in this population. Interventions to increase Hgb above this level may be of limited benefit. Springer Science+Business Media, LLC, 2011 Blood transfusions nationallicence Congenital heart disease nationallicence Univentricular heart nationallicence Infant nationallicence Intensive care nationallicence Kuo James Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA aut Maher Kevin Department of Pediatrics, Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA aut Kirshbom Paul Division of Cardiothoracic Surgery, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA aut Mahle William Department of Pediatrics, Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA aut Pediatric Cardiology Springer-Verlag 32/4(2011-04-01), 461-468 0172-0643 32:4<461 2011 32 246 https://doi.org/10.1007/s00246-011-9901-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9901-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuo James Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Maher Kevin Department of Pediatrics, Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Kirshbom Paul Division of Cardiothoracic Surgery, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Mahle William Department of Pediatrics, Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/4(2011-04-01), 461-468 0172-0643 32:4<461 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer