caa a22 4500 445824816 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00246-011-9892-0 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9892-0 P-Wave Dispersion and Heart Rate Variability in Children with Mitral Valve Prolapse [Elektronische Daten] [Kadir Babaoglu, Gürkan Altun, Köksal Binnetoğlu] Previous studies have reported that patients with mitral valve prolapse (MVP) may display autonomic dysfunction. Measurement of heart rate variability (HRV) and P-wave dispersion (PWD) may provide insights into the functional state of the autonomic nervous system. Heart rate variability (HRV) has been used as a noninvasive marker of autonomic activity. However, to the authors' knowledge, PWD has not been studied in the context of MVP. This study aimed to examine HRV and PWD in patients with MVP and to determine whether differences exist between symptomatic and asymptomatic patients. The study population consisted of 54 healthy children (17 boys and 37 girls) ages 6-18years and 76 patients with MVP (20 boys and 56 girls) ages 6-18years. The duration and dispersion of the P-wave were measured by surface 12-lead electrocardiograms (ECGs). Heart rate variability was quantified using both time-domain and frequency-domain analyses of Holter ECGs. The minimum duration of the P-wave was significantly lower in the MVP patients (42.4±10.0ms) than in the control subjects (54.4±12.8ms) (p<0.01), and the PWD was significantly increased in the MVP group (42.7±10.8ms) compared with the control subjects (31.8±10.9ms) (p<0.01). However, no significant differences were found between the symptomatic and asymptomatic patients. In addition, the HRV parameters were not statistically different between the two groups. In conclusion, although HRV parameters were not significantly different between the MVP and control groups, the findings show that PWD was increased for the children with MVP. However, no relationship could be established between PWD and clinical symptoms. Springer Science+Business Media, LLC, 2011 Children nationallicence Heart rate variability nationallicence Mitral valve prolapse nationallicence P-wave dispersion nationallicence Babaoglu Kadir Department of Pediatric Cardiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey aut Altun Gürkan Department of Pediatric Cardiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey aut Binnetoğlu Köksal Department of Pediatric Cardiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey aut Pediatric Cardiology Springer-Verlag 32/4(2011-04-01), 449-454 0172-0643 32:4<449 2011 32 246 https://doi.org/10.1007/s00246-011-9892-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9892-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Babaoglu Kadir Department of Pediatric Cardiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey aut NATIONALLICENCE 700 1- Altun Gürkan Department of Pediatric Cardiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey aut NATIONALLICENCE 700 1- Binnetoğlu Köksal Department of Pediatric Cardiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/4(2011-04-01), 449-454 0172-0643 32:4<449 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer