caa a22 4500 445824905 CHVBK 20180317145256.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00246-011-9900-4 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9900-4 The Functions of Endothelial Progenitor Cells Were Significantly Improved After Treatment With Intravenous Immunoglobulin and Aspirin in Children With Kawasaki Disease [Elektronische Daten] [Ming Xu, Li Men, Ying Zu, Chun Zhao, Xiang Meng, Tao Wang] We sought to determine the effects of treatment with intravenous immunoglobulin (IVIG) and aspirin on the functions of endothelial progenitor cells (EPCs) in patients with Kawasaki disease (KD) as well as its relationship with concentrations of tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP). Ten KD patients in the acute phase of their disease were recruited. We investigated EPC functions in children with KD before and after treatment with IVIG and aspirin. In vitro assays were used to measure the functions, including proliferation, adhesion, and migration activities, of EPCs. Plasma levels of TNF-α and hs-CRP were also assessed. All of the data were assessed before and at 7 days after treatment initiation. EPC functions after 7 days of treatment with IVIG and aspirin were significantly improved than they were before treatment with IVIG and aspirin. Treatment with IVIG and aspirin significantly decreased TNF-α and hs-CRP concentrations. There was a significant linear regression relationship between decreased plasma TNF-α levels, hs-CRP levels, and increased functions of circulating EPCs. The results of our study indicate that the functions of circulating EPCs improved after treatment with IVIG and aspirin, which may be related to decreased concentrations of TNF-α and hs-CRP. Springer Science+Business Media, LLC, 2011 Kawasaki disease nationallicence Intravenous immunoglobulin nationallicence Endothelial progenitor cell nationallicence Xu Ming The Cardiovascular Center, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut Men Li The Neurology Department, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut Zu Ying The Pediatric Research Institute, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut Zhao Chun The Cardiovascular Center, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut Meng Xiang The Cardiovascular Center, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut Wang Tao The Cardiovascular Center, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut Pediatric Cardiology Springer-Verlag 32/4(2011-04-01), 455-460 0172-0643 32:4<455 2011 32 246 https://doi.org/10.1007/s00246-011-9900-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9900-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xu Ming The Cardiovascular Center, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut NATIONALLICENCE 700 1- Men Li The Neurology Department, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut NATIONALLICENCE 700 1- Zu Ying The Pediatric Research Institute, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut NATIONALLICENCE 700 1- Zhao Chun The Cardiovascular Center, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut NATIONALLICENCE 700 1- Meng Xiang The Cardiovascular Center, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut NATIONALLICENCE 700 1- Wang Tao The Cardiovascular Center, Shen-Zhen Children's Hospital, No. 7019, Yi Tian Rd, Fu Tian District, 518026, Shen-Zhen, China aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/4(2011-04-01), 455-460 0172-0643 32:4<455 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer