caa a22 4500 44582493X CHVBK 20180317145256.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00246-010-9858-7 doi (NATIONALLICENCE)springer-10.1007/s00246-010-9858-7 Coding Single-Nucleotide Polymorphisms of Interleukin-1 Gene Cluster Are Not Associated with Kawasaki Disease in the Korean Population [Elektronische Daten] [Su Kim, Sung Kang, Joo-Ho Chung, Jong Lee, Hyun Park, Kyung Yoon, Soo Kim] This study aimed to examine whether coding single-nucleotide polymorphisms (cSNPs) of the interleukin-1 gene cluster [interleukin-1-alpha (IL1α), IL1β, IL-1-receptor antagonist (IL1RN)] are genetic markers of susceptibility to Kawasaki disease (KD) in the Korean population. The study enrolled 109 KD patients and 287 healthy control subjects. Four cSNPs [rs17561 (Ala114Ser) of IL1α, rs1143634 (Phe105Phe) of IL1β, and rs419598 (Ala23Ala) and rs315952 (Ser96Ser) of IL1RN] were genotyped using the restriction fragment-length polymorphism (RFLP) and direct sequencing. The KD patients were divided into two groups according to the presence of coronary artery lesions (CALs). For genetic analysis, SNPStats, HapAnalyzer, Helixtree, and SNPAnalyzer were used. The allele and genotype frequencies of the IL1 gene cluster polymorphisms in the KD patients had a pattern similar to that in the control subjects. Furthermore, no association was observed between four cSNPs of the IL1 gene cluster and the development of CALs in KD. These results suggest that the IL1 gene cluster may not be associated with susceptibility to KD and the development of CALs in the Korean population. Springer Science+Business Media, LLC, 2011 Coronary artery lesions nationallicence Interleukin-1-alpha nationallicence Interleukin-1-beta nationallicence Interleukin-1 gene cluster nationallicence Interleukin 1-receptor antagonist nationallicence Kawasaki disease nationallicence Polymorphism nationallicence Kim Su Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, 130-701, Seoul, Republic of Korea aut Kang Sung Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, 130-701, Seoul, Republic of Korea aut Chung Joo-Ho Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, 130-701, Seoul, Republic of Korea aut Lee Jong Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, 130-701, Seoul, Republic of Korea aut Park Hyun Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, 130-701, Seoul, Republic of Korea aut Yoon Kyung Department of Pediatrics, East-West Neo Medical Center, Kyung Hee University, Sangil-dong, Gangdong-gu, 134-890, Seoul, Republic of Korea aut Kim Soo Department of Thoracic and Cardiovascular Surgery, Kyung Hee University Medical Center, Kyung Hee University, Hoegi-dong, Dongdarmun-gu, 130-702, Seoul, Republic of Korea aut Pediatric Cardiology Springer-Verlag 32/4(2011-04-01), 381-385 0172-0643 32:4<381 2011 32 246 https://doi.org/10.1007/s00246-010-9858-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9858-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Su Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, 130-701, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kang Sung Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, 130-701, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Chung Joo-Ho Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, 130-701, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Lee Jong Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, 130-701, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Park Hyun Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, 130-701, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Yoon Kyung Department of Pediatrics, East-West Neo Medical Center, Kyung Hee University, Sangil-dong, Gangdong-gu, 134-890, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Soo Department of Thoracic and Cardiovascular Surgery, Kyung Hee University Medical Center, Kyung Hee University, Hoegi-dong, Dongdarmun-gu, 130-702, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/4(2011-04-01), 381-385 0172-0643 32:4<381 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer