caa a22 4500 445825138 CHVBK 20180317145256.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00246-010-9866-7 doi (NATIONALLICENCE)springer-10.1007/s00246-010-9866-7 Multicenter Study of the Effectiveness of Implantable Cardioverter Defibrillators in Children and Young Adults With Heart Disease [Elektronische Daten] [Nicholas Von Bergen, Dianne Atkins, Macdonald Dick II, David Bradley, Susan Etheridge, Elizabeth Saarel, Peter Fischbach, Seshadri Balaji, Narayanswami Sreeram, William Evans, Ian Law] Implantable cardioverter defibrillators (ICDs) are being used with increasing frequency in children and young adults. Our aim was to examine the appropriateness and frequency of ICD discharges in children and young adults, to compare the effectiveness of ICDs when placed for primary or secondary prevention, and to provide time-dependent analysis of ICD discharges. Data were collected from seven institutions on 210 patients <30years of age who underwent ICD implantation from October 1992 to January 2007. Median age at implant was 15.4years with a follow-up average of 3.3years. Heart disease was categorized as electrical (n=90, 42%), cardiomyopathic (n=62, 30%), or congenital heart disease (n=58, 28%). ICDs are increasingly placed for primary prevention. There are increased appropriate ICD discharges for ICDs placed for secondary prevention (52%) versus primary prevention (14%) at 5years. There is no difference in the risk of inappropriate discharges between primary and secondary prevention indications. There is an increased risk for inappropriate therapy in the congenital heart disease population. An increasing number of ICDs are being placed for primary prevention in young patients, a marked shift in practice during the last two decades. The benefits of ICDs remain greater in secondary than in primary-prevention patients. In both groups, approximately 25% of patients received inappropriate discharges within 5years of implant. Patients with congenital heart disease are the most affected by inappropriate discharges. Springer Science+Business Media, LLC, 2010 Implantable cardioverter defibrillator nationallicence Congenital heart disease nationallicence Pediatrics nationallicence Long QT syndrome nationallicence Defibrillation nationallicence Sudden cardiac death nationallicence Von Bergen Nicholas Department of Pediatric Cardiology, Carver College of Medicine, University of Iowa Children's Hospital, University of Iowa, Iowa City, IA, USA aut Atkins Dianne Department of Pediatric Cardiology, Carver College of Medicine, University of Iowa Children's Hospital, University of Iowa, Iowa City, IA, USA aut Dick II Macdonald Department of Pediatric Cardiology, University of Michigan Congenital Heart Center, University of Michigan, Ann Arbor, MI, USA aut Bradley David Department of Pediatric Cardiology, University of Michigan Congenital Heart Center, University of Michigan, Ann Arbor, MI, USA aut Etheridge Susan Department of Pediatric Cardiology, Primary Children's Medical Center and The University of Utah School of Medicine, Salt Lake City, UT, USA aut Saarel Elizabeth Department of Pediatric Cardiology, Primary Children's Medical Center and The University of Utah School of Medicine, Salt Lake City, UT, USA aut Fischbach Peter Department of Pediatric Cardiology, Sibley Heart Center, Atlanta, GA, USA aut Balaji Seshadri Department of Pediatric Cardiology, Oregon Heath Sciences, Portland, OR, USA aut Sreeram Narayanswami Department of Pediatric Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany aut Evans William Department of Pediatric Cardiology, Las Vegas Children's Heart Center, Las Vegas, NV, USA aut Law Ian Department of Pediatric Cardiology, Carver College of Medicine, University of Iowa Children's Hospital, University of Iowa, Iowa City, IA, USA aut Pediatric Cardiology Springer-Verlag 32/4(2011-04-01), 399-405 0172-0643 32:4<399 2011 32 246 https://doi.org/10.1007/s00246-010-9866-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9866-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Von Bergen Nicholas Department of Pediatric Cardiology, Carver College of Medicine, University of Iowa Children's Hospital, University of Iowa, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Atkins Dianne Department of Pediatric Cardiology, Carver College of Medicine, University of Iowa Children's Hospital, University of Iowa, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Dick II Macdonald Department of Pediatric Cardiology, University of Michigan Congenital Heart Center, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Bradley David Department of Pediatric Cardiology, University of Michigan Congenital Heart Center, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Etheridge Susan Department of Pediatric Cardiology, Primary Children's Medical Center and The University of Utah School of Medicine, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Saarel Elizabeth Department of Pediatric Cardiology, Primary Children's Medical Center and The University of Utah School of Medicine, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Fischbach Peter Department of Pediatric Cardiology, Sibley Heart Center, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Balaji Seshadri Department of Pediatric Cardiology, Oregon Heath Sciences, Portland, OR, USA aut NATIONALLICENCE 700 1- Sreeram Narayanswami Department of Pediatric Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Evans William Department of Pediatric Cardiology, Las Vegas Children's Heart Center, Las Vegas, NV, USA aut NATIONALLICENCE 700 1- Law Ian Department of Pediatric Cardiology, Carver College of Medicine, University of Iowa Children's Hospital, University of Iowa, Iowa City, IA, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/4(2011-04-01), 399-405 0172-0643 32:4<399 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer