caa a22 4500 445825189 CHVBK 20180317145257.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00246-011-0035-4 doi (NATIONALLICENCE)springer-10.1007/s00246-011-0035-4 Accuracy of Doppler-Derived Estimation of Pulmonary Vascular Resistance in Congenital Heart Disease: An Index of Operability [Elektronische Daten] [Gholam Ajami, Sirous Cheriki, Hamid Amoozgar, Mohammad Borzouee, Manoucher Soltani] Pulmonary vascular resistance (PVR) is a critical and essential parameter during the assessment and selection of modality of treatment in patients with congenital heart disease (CHD) accompanied by pulmonary arterial hypertension (PAH). Cardiac catheterization is the "gold standard” but is an invasive method for PVR measurement. A noninvasive and reliable method for estimation of PVR in children has been a major challenge and most desirable during past decades, especially for those who need repeated measurements. In a prospective study and among consecutive patients who were referred for cardiac catheterizations, PVR was calculated as the ratio of the transpulmonary pressure gradient (∆P) to the amount of the pulmonary flow (QP) accordingly for 20 patients with CHD and high PAH. Subsequently and noninvasively, PVR was assessed for these patients by a Doppler echocardiography-derived index defined as the ratio of the tricuspid regurgitation velocity (TRVm/s) to the velocity time integral (VTIcm) of the right-ventricular outflow tract (RVOT). There was a good correlation between PVR measured at catheterization (PVRcath) and TRV/VTIm ratio; the mean of three measurements of VTI (VTIm) with R 2=0.53 (p=0.008). In addition, a TRV/VTIm value of 0.2 provided a sensitivity of 71.4% and a specificity of 100% for PVR >6 Woods units (WU) as well as sensitivity of 90% and specificity of 90% for a PVR equal to 8 WU. PVR value between 6 and 8 WU by catheterization has been considered as a cut-off point for intervention in children with left-to-right shunts and PAH. In conclusion, Doppler-derived TRV/VTIm ratio is a reliable index that may be helpful as a supplementary diagnostic tool for the selection of modality of treatment and follow-up of patients with PAH and increased PVR. Springer Science+Business Media, LLC, 2011 Congenital heart disease nationallicence Pulmonary arterial hypertension nationallicence Pulmonary vascular resistance nationallicence Noninvasive nationallicence Doppler estimation nationallicence Ajami Gholam Department of Pediatrics, Division of Pediatric Cardiology, Namazi Hospital, Shiraz University of Medical Sciences, 71937-11351, Shiraz, Iran aut Cheriki Sirous Department of Pediatrics, Division of Pediatric Cardiology, Namazi Hospital, Shiraz University of Medical Sciences, 71937-11351, Shiraz, Iran aut Amoozgar Hamid Department of Pediatrics, Division of Pediatric Cardiology, Namazi Hospital, Shiraz University of Medical Sciences, 71937-11351, Shiraz, Iran aut Borzouee Mohammad Department of Pediatrics, Division of Pediatric Cardiology, Namazi Hospital, Shiraz University of Medical Sciences, 71937-11351, Shiraz, Iran aut Soltani Manoucher Department of Pediatrics, Division of Pediatric Cardiology, Namazi Hospital, Shiraz University of Medical Sciences, 71937-11351, Shiraz, Iran aut Pediatric Cardiology Springer-Verlag 32/8(2011-12-01), 1168-1174 0172-0643 32:8<1168 2011 32 246 https://doi.org/10.1007/s00246-011-0035-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-0035-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ajami Gholam Department of Pediatrics, Division of Pediatric Cardiology, Namazi Hospital, Shiraz University of Medical Sciences, 71937-11351, Shiraz, Iran aut NATIONALLICENCE 700 1- Cheriki Sirous Department of Pediatrics, Division of Pediatric Cardiology, Namazi Hospital, Shiraz University of Medical Sciences, 71937-11351, Shiraz, Iran aut NATIONALLICENCE 700 1- Amoozgar Hamid Department of Pediatrics, Division of Pediatric Cardiology, Namazi Hospital, Shiraz University of Medical Sciences, 71937-11351, Shiraz, Iran aut NATIONALLICENCE 700 1- Borzouee Mohammad Department of Pediatrics, Division of Pediatric Cardiology, Namazi Hospital, Shiraz University of Medical Sciences, 71937-11351, Shiraz, Iran aut NATIONALLICENCE 700 1- Soltani Manoucher Department of Pediatrics, Division of Pediatric Cardiology, Namazi Hospital, Shiraz University of Medical Sciences, 71937-11351, Shiraz, Iran aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/8(2011-12-01), 1168-1174 0172-0643 32:8<1168 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer