caa a22 4500 445825251 CHVBK 20180317145257.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00246-011-9986-8 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9986-8 Prediction of the Risk of Coronary Arterial Lesions in Kawasaki Disease by Brain Natriuretic Peptide [Elektronische Daten] [Kazunari Kaneko, Ken Yoshimura, Atsushi Ohashi, Takahisa Kimata, Tomohiko Shimo, Shoji Tsuji] Kawasaki disease (KD) is an acute systemic vasculitis associated with the development of coronary arterial lesions (CALs) occurring in 3-5% of children treated by intravenous immune globulin (IVIG). However, a considerable number of patients who are not responding to IVIG are at much higher risk. Although studies have explored potential biomarkers to predict patients with KD who are at risk of CAL, no useful single marker exists. We hypothesized that the serum concentrations of the N-terminal moiety of brain natriuretic peptide (NT-proBNP) can be useful to predict CAL. Forty-three children with KD (29 males and 14 females) were enrolled in this study. Despite IVIG, 6 of the 43 patients developed CAL. There were, however, no significant differences in variables between children with CAL and those without CAL: These include age, gender, day of the illness, leukocyte count, and the serum levels of sodium, C-reactive protein, and albumin. The serum NT-proBNP level was significantly higher in children with CAL than those without CAL (2,611±1,699 vs. 1,073±1,427pg/ml; P=0.03): the cutoff value of 1,000pg/ml to predict CAL produced a specificity of 0.68, sensitivity of 0.83, and an odds ratio as high as 10.4. In conclusion, NT-proBNP is increased in KD patients who are developing CAL, and patients with an elevated serum NT-proBNP>1,000pg/ml have a risk of CAL~10 times higher than that of patients with a modest increase. Springer Science+Business Media, LLC, 2011 Kawasaki disease nationallicence Coronary arterial lesion nationallicence Brain natriuretic peptide nationallicence Kaneko Kazunari Department of Pediatrics, Kansai Medical University, Osaka, Japan aut Yoshimura Ken Department of Pediatrics, Kansai Medical University, Osaka, Japan aut Ohashi Atsushi Department of Pediatrics, Kansai Medical University, Osaka, Japan aut Kimata Takahisa Department of Pediatrics, Kansai Medical University, Osaka, Japan aut Shimo Tomohiko Department of Pediatrics, Kansai Medical University, Osaka, Japan aut Tsuji Shoji Department of Pediatrics, Kansai Medical University, Osaka, Japan aut Pediatric Cardiology Springer-Verlag 32/8(2011-12-01), 1106-1109 0172-0643 32:8<1106 2011 32 246 https://doi.org/10.1007/s00246-011-9986-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9986-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaneko Kazunari Department of Pediatrics, Kansai Medical University, Osaka, Japan aut NATIONALLICENCE 700 1- Yoshimura Ken Department of Pediatrics, Kansai Medical University, Osaka, Japan aut NATIONALLICENCE 700 1- Ohashi Atsushi Department of Pediatrics, Kansai Medical University, Osaka, Japan aut NATIONALLICENCE 700 1- Kimata Takahisa Department of Pediatrics, Kansai Medical University, Osaka, Japan aut NATIONALLICENCE 700 1- Shimo Tomohiko Department of Pediatrics, Kansai Medical University, Osaka, Japan aut NATIONALLICENCE 700 1- Tsuji Shoji Department of Pediatrics, Kansai Medical University, Osaka, Japan aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/8(2011-12-01), 1106-1109 0172-0643 32:8<1106 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer