caa a22 4500 445825413 CHVBK 20180317145257.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00246-011-0036-3 doi (NATIONALLICENCE)springer-10.1007/s00246-011-0036-3 Outcomes and Risk Factors for Mortality in Premature Neonates With Critical Congenital Heart Disease [Elektronische Daten] [Henry Cheng, Melvin Almodovar, Peter Laussen, David Wypij, Angelo Polito, David Brown, Sitaram Emani, Frank Pigula, Catherine Allan, John Costello] We sought to describe contemporary outcomes and identify risk factors for hospital mortality in premature neonates with critical congenital heart disease who were referred for early intervention. Neonates who were born before 37weeks' gestation with critical congenital heart disease and admitted to our institution from 2002 to 2008 were included in this retrospective cohort study. Critical congenital heart disease was defined as a defect requiring surgical or transcatheter cardiac intervention or a defect resulting in death within the first 28days of life. Logistic regression analyses were performed to identify risk factors for mortality before hospital discharge. The study included 180 premature neonates, of whom 37 (21%) died during their initial hospitalization, including 6 (4%) before cardiac intervention and 31 (17%) after cardiac intervention. For the 174 patients undergoing cardiac intervention, independent risk factors for mortality were a 5min Apgar score≤7, need for preintervention mechanical ventilation, and Risk Adjustment in Congenital Heart Surgery category≥4 or not assignable. Mortality for premature infants with critical congenital heart disease who are referred for early intervention remains high. Patients with lower Apgar scores who receive preintervention mechanical ventilation and undergo more complex procedures are at greatest risk. Springer Science+Business Media, LLC, 2011 Gestational age nationallicence Heart defects, congenital nationallicence Intensive care nationallicence Premature birth nationallicence Cheng Henry Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut Almodovar Melvin Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut Laussen Peter Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut Wypij David Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut Polito Angelo Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut Brown David Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut Emani Sitaram Department of Cardiac Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut Pigula Frank Department of Cardiac Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut Allan Catherine Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut Costello John Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut Pediatric Cardiology Springer-Verlag 32/8(2011-12-01), 1139-1146 0172-0643 32:8<1139 2011 32 246 https://doi.org/10.1007/s00246-011-0036-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-0036-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cheng Henry Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Almodovar Melvin Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Laussen Peter Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Wypij David Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Polito Angelo Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Brown David Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Emani Sitaram Department of Cardiac Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Pigula Frank Department of Cardiac Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Allan Catherine Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Costello John Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/8(2011-12-01), 1139-1146 0172-0643 32:8<1139 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer