caa a22 4500 445825472 CHVBK 20180317145257.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00246-011-0053-2 doi (NATIONALLICENCE)springer-10.1007/s00246-011-0053-2 Outcomes of Hypoplastic Left Heart Syndrome in Low-Birth-Weight Patients [Elektronische Daten] [Sarah Gelehrter, Carlen Fifer, Aimee Armstrong, Jennifer Hirsch, Robert Gajarski] The objective of this study was to assess outcomes of hypoplastic left heart syndrome (HLHS) patients weighing ≤2.5kg throughout staged palliation. We performed a single-center retrospective review. Abstracted data included gestational age, birth weight, presence of noncardiac anomalies, and survival through Fontan. Fifty-two patients met inclusion criteria, with a median birth weight of 2.14kg and gestational age of 36weeks. Five patients received comfort care only. Of 47 patients who underwent initial surgical palliation, 51% survived to initial hospital discharge. Birth weight and gestational age (GA) were similar between survivors and nonsurvivors. Compared with survivors, risk factors for death prior to initial hospital discharge were as follows: small for GA (P=0.005), noncardiac anomalies (P=0.04), need for post-perative extracorporeal membrane oxygenation (P=0.0004), and conversion from initial palliation to Sano shunt (n=5, no survivors). Operative survival following Stage 2 palliation was 91% (21/23) and 94% after Fontan (17/18). Overall survival for palliated patients from birth through Fontan was 36%. Low-birth-weight neonates with HLHS have poor overall survival through the Fontan operation, with highest mortality following Stage 1 palliation. Being small for GA and the presence of noncardiac anomalies are important preoperative risk factors for early mortality. Springer Science+Business Media, LLC, 2011 Congenital heart disease nationallicence Hypoplastic left heart syndrome nationallicence Low birth weight nationallicence Premature nationallicence Gelehrter Sarah Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, MI, USA aut Fifer Carlen Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, MI, USA aut Armstrong Aimee Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, MI, USA aut Hirsch Jennifer Section of Cardiac Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA aut Gajarski Robert Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, MI, USA aut Pediatric Cardiology Springer-Verlag 32/8(2011-12-01), 1175-1181 0172-0643 32:8<1175 2011 32 246 https://doi.org/10.1007/s00246-011-0053-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-0053-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gelehrter Sarah Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Fifer Carlen Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Armstrong Aimee Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Hirsch Jennifer Section of Cardiac Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Gajarski Robert Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/8(2011-12-01), 1175-1181 0172-0643 32:8<1175 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer