caa a22 4500 445825545 CHVBK 20180317145258.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00246-011-9980-1 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9980-1 The Myocardium of Fetuses with Endocardial Fibroelastosis Contains Fewer B and T Lymphocytes than Normal Control Myocardium [Elektronische Daten] [Nisha Fernandes, Glenn Taylor, Cedric Manlhiot, Brian McCrindle, Michael Ho, Steven Miner, Adelle Atkinson, Edgar Jaeggi, Lynne Nield] The observation that endocardial fibroelastosis (EFE) can result from an immune response to maternal autoantibody deposition in the fetal myocardium raises the possibility that the fetal immune system may contribute to the pathogenesis of idiopathic EFE and dilated cardiomyopathy (DCM). This study sought to characterize myocardial immune cell presence in fetuses and neonates with idiopathic EFE+DCM, in those with EFE+structural heart disease, and in normal control subjects. Paraffin tissue sections from fetuses identified from the pathology database were stained for B cell, T cell, macrophage, and general hematopoietic cell surface markers. Of the 14 fetuses included in the study, 5 had EFE+DCM, 4 had EFE+structural heart disease, and 5 were normal control fetuses. The EFE+DCM group had fewer B cells than the control group (0.15 vs. 0.44cells/mm2; p=0.005). The EFE+heart disease group had both fewer B cells (0.18 vs. 0.44cells/mm2; p=0.08) and T cells (0.29 vs. 0.80 cells/mm2; p=0.04) than the control group. The CD4/CD8 ratio was similar in the EFE+DCM and EFE+heart disease groups (1.0 vs. 0.9; p=0.17) but higher in the EFE+DCM group than in the control group (0.9 vs. 0.3; p=0.03). The myocardium of fetuses with EFE contains fewer B and T lymphocytes than normal control fetuses. Springer Science+Business Media, LLC, 2011 Dilated cardiomyopathy nationallicence Endocardial fibroelastosis nationallicence Immune cells nationallicence Fernandes Nisha The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, M5G 1X8, Toronto, ON, Canada aut Taylor Glenn The Hospital for Sick Children, Division of Pathology, University of Toronto, M5G 1X8, Toronto, ON, Canada aut Manlhiot Cedric The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, M5G 1X8, Toronto, ON, Canada aut McCrindle Brian The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, M5G 1X8, Toronto, ON, Canada aut Ho Michael The Hospital for Sick Children, Division of Pathology, University of Toronto, M5G 1X8, Toronto, ON, Canada aut Miner Steven Southlake Regional Health Centre, Newmarket, ON, Canada aut Atkinson Adelle The Hospital for Sick Children, Division of Immunology and Allergy, University of Toronto, M5G 1X8, Toronto, ON, Canada aut Jaeggi Edgar The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, M5G 1X8, Toronto, ON, Canada aut Nield Lynne The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, M5G 1X8, Toronto, ON, Canada aut Pediatric Cardiology Springer-Verlag 32/8(2011-12-01), 1088-1095 0172-0643 32:8<1088 2011 32 246 https://doi.org/10.1007/s00246-011-9980-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9980-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fernandes Nisha The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, M5G 1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Taylor Glenn The Hospital for Sick Children, Division of Pathology, University of Toronto, M5G 1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Manlhiot Cedric The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, M5G 1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- McCrindle Brian The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, M5G 1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Ho Michael The Hospital for Sick Children, Division of Pathology, University of Toronto, M5G 1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Miner Steven Southlake Regional Health Centre, Newmarket, ON, Canada aut NATIONALLICENCE 700 1- Atkinson Adelle The Hospital for Sick Children, Division of Immunology and Allergy, University of Toronto, M5G 1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Jaeggi Edgar The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, M5G 1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Nield Lynne The Hospital for Sick Children, Labatt Family Heart Centre, University of Toronto, M5G 1X8, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/8(2011-12-01), 1088-1095 0172-0643 32:8<1088 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer