caa a22 4500 445825693 CHVBK 20180317145258.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00246-011-9917-8 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9917-8 Reproducibility of Oxygen Saturation Monitoring During Six-Minute Walk Test and Exercise Stress Test in Patients with Pulmonary Arteriovenous Malformations Associated With Hereditary Hemorrhagic Telangiectasia [Elektronische Daten] [Walter Li, Bolin Niu, Katherine Henderson, Veronika Northrup, Jeffery Pollak, Terence Trow, John Fahey, Robert White Jr.] Patients with pulmonary arteriovenous malformations (PAVMs) are at risk for multiple complications and require close follow-up. We investigated the reproducibility of the 6-minute walk test (6MWT) and exercise stress test (EST) for the evaluation of low oxygen saturation in patients with PAVMs. Twenty-two patients with PAVMs, most of whom had hereditary hemorrhagic telangiectasia (HHT), participated in a Human Investigations Committee-approved protocol. Patients ranged from 9 to 74years of age (mean 28) and had a broad spectrum of anatomic subtypes of PAVMs, including focal and diffuse. Standard 6MWT and cycle ergometry EST were both performed twice with adequate rest between tests. Heart rate (HR) and oxygen saturation were measured at the beginning and end of each test. Distance walked and maximum resistance was also recorded. The intraclass correlation coefficients (ri) at the end of 6MWT were as follows: HR (ri=0.940; 95% confidence interval [CI] 0.863-0.975), oxygen saturation (ri=0.973; 95% CI 0.933-0.989), and distance (ri=0.942; 95% CI 0.867-0.975). The ris at the end of EST were as follows: HR (ri=0.941; 95% CI 0.865-0.975), oxygen saturation (ri=0.993; 95% CI 0.982-0.997), and maximum resistance (ri=0.941; 95% CI 0.864-0.975). 6MWT and EST were reproducible measures of exercise capacity and oxygen saturation and are potential adjunct tests in the follow-up assessment for patients with PAVMs. Springer Science+Business Media, LLC, 2011 Pulmonary arteriovenous malformation nationallicence Hereditary hemorrhagic telangiectasia nationallicence Exercise nationallicence Li Walter Department of Pediatrics, Section of Pediatric Cardiology, Yale University School of Medicine, 06520-8064, New Haven, CT, USA aut Niu Bolin Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, USA aut Henderson Katherine Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, USA aut Northrup Veronika Yale University School of Public Health, Yale Center for Analytical Sciences, New Haven, USA aut Pollak Jeffery Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, USA aut Trow Terence Department of Internal Medicine, Yale University School of Medicine, New Haven, USA aut Fahey John Department of Pediatrics, Section of Pediatric Cardiology, Yale University School of Medicine, 06520-8064, New Haven, CT, USA aut White Jr. Robert Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, USA aut Pediatric Cardiology Springer-Verlag 32/5(2011-06-01), 590-594 0172-0643 32:5<590 2011 32 246 https://doi.org/10.1007/s00246-011-9917-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9917-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Walter Department of Pediatrics, Section of Pediatric Cardiology, Yale University School of Medicine, 06520-8064, New Haven, CT, USA aut NATIONALLICENCE 700 1- Niu Bolin Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, USA aut NATIONALLICENCE 700 1- Henderson Katherine Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, USA aut NATIONALLICENCE 700 1- Northrup Veronika Yale University School of Public Health, Yale Center for Analytical Sciences, New Haven, USA aut NATIONALLICENCE 700 1- Pollak Jeffery Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, USA aut NATIONALLICENCE 700 1- Trow Terence Department of Internal Medicine, Yale University School of Medicine, New Haven, USA aut NATIONALLICENCE 700 1- Fahey John Department of Pediatrics, Section of Pediatric Cardiology, Yale University School of Medicine, 06520-8064, New Haven, CT, USA aut NATIONALLICENCE 700 1- White Jr Robert Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/5(2011-06-01), 590-594 0172-0643 32:5<590 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer