caa a22 4500 445825766 CHVBK 20180317145258.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00246-011-9909-8 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9909-8 Relationship of Brain Natriuretic Peptide Concentrations to Left Ventricular Function and Adverse Outcomes in Children With End-Stage Renal Disease Undergoing Hemodialysis [Elektronische Daten] [Sana Ouali, Iheb Bougmiza, Saoussen Abroug, Asma Omezzine, Helmi Salem, Elyes Neffeti, Fahmi Remedi, Ali Bouslema, Abdelaziz Harabi, Essia Boughzela] B-type natriuretic peptide (BNP) is a biomarker of cardiovascular disease that is common in adults with chronic kidney disease (CKD). However, in children with CKD, the range and predictive power of BNP concentrations are not known. We aimed to determine the effect of HD on BNP, as well as the prognostic impact of BNP, in end-stage renal disease (ESRD) children undergoing hemodialysis (HD). Thirty-five children with chronic renal failure (16 boys age 12.1±3.7years) on maintenance HD were included. BNP level was measured, and Doppler echocardiography was performed 30min before (pre-HD BNP) and 30min after (post-HD BNP) HD in each patient. An adverse event was defined as all-cause death and heart failure hospitalization. The median pre-HD BNP, the post-HD BNP, and the change in BNP were, respectively, 240pg/ml (72 to 3346), 318pg/ml (79 to 3788), and 9pg/ml (−442 to 1889). Pre-HD BNP concentration was negatively correlated with left ventricular (LV) ejection fraction (r=−0.41, P=0.018). During a mean follow-up of 39±14months, 6 patients died, and 3 were hospitalized for heart failure. Using univariate analysis, BNP before and after HD as well as Doppler tissue imaging velocities had a strong graded relationship with adverse events. Cox proportional hazards model demonstrated that pre-HD body weight (P=0.008), pre-HD BNP (P=0.011), and post-HD BNP (P=0.038) remained independent predictors of adverse outcome. Even in case of ESRD, BNP still strongly correlated with LV systolic and diastolic dysfunction and was associated with mortality in HD children. Springer Science+Business Media, LLC, 2011 Children nationallicence Hemodialysis nationallicence Biomarkers nationallicence Ouali Sana Department of Cardiology, Sahloul Hospital, Cité Sahloul 5054, Sousse, Tunisia aut Bougmiza Iheb Department of Community Medicine, Faculty of Medicine, Sahloul Hospital, Sousse, Tunisia aut Abroug Saoussen Department of Pediatrics, Sahloul Hospital, Sousse, Tunisia aut Omezzine Asma Department of Biochemistry, Sahloul Hospital, Sousse, Tunisia aut Salem Helmi Department of Cardiology, Sahloul Hospital, Cité Sahloul 5054, Sousse, Tunisia aut Neffeti Elyes Department of Cardiology, Sahloul Hospital, Cité Sahloul 5054, Sousse, Tunisia aut Remedi Fahmi Department of Cardiology, Sahloul Hospital, Cité Sahloul 5054, Sousse, Tunisia aut Bouslema Ali Department of Biochemistry, Sahloul Hospital, Sousse, Tunisia aut Harabi Abdelaziz Department of Pediatrics, Sahloul Hospital, Sousse, Tunisia aut Boughzela Essia Department of Cardiology, Sahloul Hospital, Cité Sahloul 5054, Sousse, Tunisia aut Pediatric Cardiology Springer-Verlag 32/5(2011-06-01), 568-577 0172-0643 32:5<568 2011 32 246 https://doi.org/10.1007/s00246-011-9909-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9909-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ouali Sana Department of Cardiology, Sahloul Hospital, Cité Sahloul 5054, Sousse, Tunisia aut NATIONALLICENCE 700 1- Bougmiza Iheb Department of Community Medicine, Faculty of Medicine, Sahloul Hospital, Sousse, Tunisia aut NATIONALLICENCE 700 1- Abroug Saoussen Department of Pediatrics, Sahloul Hospital, Sousse, Tunisia aut NATIONALLICENCE 700 1- Omezzine Asma Department of Biochemistry, Sahloul Hospital, Sousse, Tunisia aut NATIONALLICENCE 700 1- Salem Helmi Department of Cardiology, Sahloul Hospital, Cité Sahloul 5054, Sousse, Tunisia aut NATIONALLICENCE 700 1- Neffeti Elyes Department of Cardiology, Sahloul Hospital, Cité Sahloul 5054, Sousse, Tunisia aut NATIONALLICENCE 700 1- Remedi Fahmi Department of Cardiology, Sahloul Hospital, Cité Sahloul 5054, Sousse, Tunisia aut NATIONALLICENCE 700 1- Bouslema Ali Department of Biochemistry, Sahloul Hospital, Sousse, Tunisia aut NATIONALLICENCE 700 1- Harabi Abdelaziz Department of Pediatrics, Sahloul Hospital, Sousse, Tunisia aut NATIONALLICENCE 700 1- Boughzela Essia Department of Cardiology, Sahloul Hospital, Cité Sahloul 5054, Sousse, Tunisia aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/5(2011-06-01), 568-577 0172-0643 32:5<568 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer