caa a22 4500 445825782 CHVBK 20180317145258.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00246-011-9948-1 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9948-1 Utility of Doppler Tissue Imaging-Derived Indices in Identifying Subclinical Systolic Ventricular Dysfunction in Children With Restrictive Cardiomyopathy [Elektronische Daten] [Nao Sasaki, Mario Garcia, Irene Lytrivi, H. Ko, James Nielsen, Ira Parness, Shubhika Srivastava] Restrictive cardiomyopathy (RCM) is characterized by irreversible diastolic dysfunction with preserved systolic function. The aim of this study was to investigate the presence of impaired ventricular contractility even in the presence of normal ejection fraction (EF) in children with RCM. Longitudinal Doppler tissue velocities were obtained from apical 4-chamber view at three locations—the left-ventricular (LV) lateral wall, the septum, and the right ventricle—in 8 children age 3-17years old with RCM who had LV EF >55%. Peak systolic velocity (S′), acceleration during isovolumic contraction (IVA), and myocardial performance index (MPI) were measured. Data from the RCM group were compared with those from 24 age- and sex-matched controls. Both S′ and IVA were markedly lower at the septum (S′ 6.2±1.7 vs. 9.2±1.6, P<0.001; IVA 1.8±0.5 vs. 3.9±1.5, P<0.001). MPI, a measure of both diastolic and systolic function, was statistically significantly greater in the RCM group at all 3 locations (P<0.005). S′ and IVA identify global subclinical systolic dysfunction in RCM with normal EF. These findings suggest that pre-ejection abnormality and subclinical systolic dysfunction coexist with diastolic dysfunction in children with RCM. Springer Science+Business Media, LLC, 2011 Tissue doppler nationallicence Restrictive cardiomyopathy nationallicence Systolic dysfunction nationallicence Sasaki Nao Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut Garcia Mario Department of Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut Lytrivi Irene Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut Ko H. Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut Nielsen James Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut Parness Ira Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut Srivastava Shubhika Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut Pediatric Cardiology Springer-Verlag 32/5(2011-06-01), 646-651 0172-0643 32:5<646 2011 32 246 https://doi.org/10.1007/s00246-011-9948-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9948-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sasaki Nao Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut NATIONALLICENCE 700 1- Garcia Mario Department of Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut NATIONALLICENCE 700 1- Lytrivi Irene Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut NATIONALLICENCE 700 1- Ko H. Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut NATIONALLICENCE 700 1- Nielsen James Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut NATIONALLICENCE 700 1- Parness Ira Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut NATIONALLICENCE 700 1- Srivastava Shubhika Division of Pediatric Cardiology, Mount Sinai School of Medicine, 10029-6574, New York, NY, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/5(2011-06-01), 646-651 0172-0643 32:5<646 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer