caa a22 4500 445825995 CHVBK 20180317145259.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00246-010-9834-2 doi (NATIONALLICENCE)springer-10.1007/s00246-010-9834-2 Early Echocardiographic Findings in β-Thalassemia Intermedia Patients Using Standard and Tissue Doppler Methods [Elektronische Daten] [Hamid Amoozgar, Nahal Farhani, Mehran Karimi] Heart complications are among the serious problems of patients with β-thalassemia intermedia. This study aimed to evaluate myocardial function in these patients. Clinical parameters and both standard Doppler and pulsed Doppler tissue imaging parameters were compared in 51 β-thalassemia intermedia patients (mean age, 17.05±5.8years) and 20 normal subjects (mean age, 17.81±7.35years, p=0.98). In 11 patients (21.5%), pulmonary artery hypertension was detected. M-mode echocardiographic findings such as ejection fraction and fractional shortening did not show statistically significant changes (p>0.005). Pulsed Doppler showed a significant difference in the early (E) to late diastolic (A) velocity ratio of the tricuspid and mitral valve between the patients and the control subjects (p<0.05). In the pulsed tissue Doppler study, the peak systolic velocity of the septum (Ss), the peak atrial velocity of the septum (Aas), the peak systolic velocity of the tricuspid annulus (St), the peak early diastolic velocity of the tricuspid annulus (Eat), and the peak late diastolic velocity of the tricuspid annulus (Aat) were increased significantly (p<0.05). The pulse tissue Doppler of the lateral mitral annulus did not change significantly (p>0.005). The peak systolic velocity of the posterior wall and the peak late diastolic velocity of the anterior wall changed significantly (p<0.05). This study showed that β-thalassemia intermedia patients with normal M-mode and two-dimensional echocardiography had statistically significant changes in pulsed Doppler and pulsed tissue Doppler imaging. Springer Science+Business Media, LLC, 2010 Diastolic function nationallicence Doppler tissue imaging nationallicence Echocardiography nationallicence Thalassemia nationallicence Amoozgar Hamid Division of Pediatric Cardiology, Department of Pediatrics, Nemazee Hospital, Shiraz University of Medical Sciences, 7193711351, Shiraz, Iran aut Farhani Nahal Division of Pediatric Cardiology, Department of Pediatrics, Nemazee Hospital, Shiraz University of Medical Sciences, 7193711351, Shiraz, Iran aut Karimi Mehran Hematology Research Center, Shiraz University of Medical Sciences, 7193711351, Shiraz, Iran aut Pediatric Cardiology Springer-Verlag 32/2(2011-02-01), 154-159 0172-0643 32:2<154 2011 32 246 https://doi.org/10.1007/s00246-010-9834-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9834-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Amoozgar Hamid Division of Pediatric Cardiology, Department of Pediatrics, Nemazee Hospital, Shiraz University of Medical Sciences, 7193711351, Shiraz, Iran aut NATIONALLICENCE 700 1- Farhani Nahal Division of Pediatric Cardiology, Department of Pediatrics, Nemazee Hospital, Shiraz University of Medical Sciences, 7193711351, Shiraz, Iran aut NATIONALLICENCE 700 1- Karimi Mehran Hematology Research Center, Shiraz University of Medical Sciences, 7193711351, Shiraz, Iran aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/2(2011-02-01), 154-159 0172-0643 32:2<154 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer