caa a22 4500 445826053 CHVBK 20180317145259.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00246-010-9829-z doi (NATIONALLICENCE)springer-10.1007/s00246-010-9829-z Disturbance of Glucose Homeostasis After Pediatric Cardiac Surgery [Elektronische Daten] [Jennifer Verhoeven, Anita Hokken-Koelega, Marieke den Brinker, Wim Hop, Robert van Thiel, Ad Bogers, Wim Helbing, Koen Joosten] This study aimed to evaluate the time course of perioperative blood glucose levels of children undergoing cardiac surgery for congenital heart disease in relation to endogenous stress hormones, inflammatory mediators, and exogenous factors such as caloric intake and glucocorticoid use. The study prospectively included 49 children undergoing cardiac surgery. Blood glucose levels, hormonal alterations, and inflammatory responses were investigated before and at the end of surgery, then 12 and 24h afterward. In general, blood glucose levels were highest at the end of surgery. Hyperglycemia, defined as a glucose level higher than 8.3mmol/l (>150mg/dl) was present in 52% of the children at the end of surgery. Spontaneous normalization of blood glucose occurred in 94% of the children within 24h. During surgery, glucocorticoids were administered to 65% of the children, and this was the main factor associated with hyperglycemia at the end of surgery (determined by univariate analysis of variance). Hyperglycemia disappeared spontaneously without insulin therapy after 12-24h for the majority of the children. Postoperative morbidity was low in the study group, so the presumed positive effects of glucocorticoids seemed to outweigh the adverse effects of iatrogenic hyperglycemia. The Author(s), 2010 Cardiac surgery nationallicence Child nationallicence Critical illness nationallicence Glucocorticoids nationallicence Hyperglycemia nationallicence Insulin nationallicence Verhoeven Jennifer Intensive Care, Erasmus MC-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands aut Hokken-Koelega Anita Department of Pediatrics, Division of Pediatric Endocrinology, Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands aut den Brinker Marieke Intensive Care, Erasmus MC-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands aut Hop Wim Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands aut van Thiel Robert Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The Netherlands aut Bogers Ad Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The Netherlands aut Helbing Wim Department of Pediatrics, Division of Pediatric Cardiology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands aut Joosten Koen Intensive Care, Erasmus MC-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands aut Pediatric Cardiology Springer-Verlag 32/2(2011-02-01), 131-138 0172-0643 32:2<131 2011 32 246 https://doi.org/10.1007/s00246-010-9829-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9829-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Verhoeven Jennifer Intensive Care, Erasmus MC-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Hokken-Koelega Anita Department of Pediatrics, Division of Pediatric Endocrinology, Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- den Brinker Marieke Intensive Care, Erasmus MC-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Hop Wim Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- van Thiel Robert Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Bogers Ad Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Helbing Wim Department of Pediatrics, Division of Pediatric Cardiology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Joosten Koen Intensive Care, Erasmus MC-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/2(2011-02-01), 131-138 0172-0643 32:2<131 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer