caa a22 4500 445826231 CHVBK 20180317145300.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00246-010-9833-3 doi (NATIONALLICENCE)springer-10.1007/s00246-010-9833-3 A Juvenile Murine Heart Failure Model of Pressure Overload [Elektronische Daten] [Kristopher Cumbermack, Jun Cheng, Yibing Nong, William Mahle, Ronald Joyner, William Border, Mary Wagner, Derek Fyfe, Traci Leong, Yanggan Wang] Persistent pressure overload can cause cardiac hypertrophy and progressive heart failure (HF). The authors developed a pressure-overload HF model of juvenile mice to study the cardiac response to pressure overload that may be applicable to clinical processes in children. Severe thoracic aortic banding (sTAB) was performed using a 28-gauge needle for 40 juvenile (age, 3weeks) and 47 adult (age, 6weeks) C57BL/6 male mice. To monitor the structural and functional changes, M-mode echocardiography was performed for conscious mice that had undergone sTAB and sham operation. Cardiac hypertrophy, dilation, and HF occurred in both juvenile and adult mice after sTAB. Compared with adults, juvenile HF is characterized by greater impairment of ventricular contractility and less hypertrophy. In addition, juvenile mice had significantly higher rates of survival than adult mice during the early postoperative weeks. Consistent with clinical HF seen in children, juvenile banded mice demonstrated a lower growth rate than either adult banded mice or juvenile control mice that had sham operations. The authors first developed a juvenile murine model of pressure-overload HF. Learning the unique characteristics of pressure-overload HF in juveniles should aid in understanding age-specific pathologic changes for HF development in children. Springer Science+Business Media, LLC, 2010 Echocardiography nationallicence Heart failure nationallicence Hypertrophy nationallicence Murine nationallicence Cumbermack Kristopher Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut Cheng Jun Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut Nong Yibing Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut Mahle William Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut Joyner Ronald Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut Border William Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut Wagner Mary Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut Fyfe Derek Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut Leong Traci Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut Wang Yanggan Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut Pediatric Cardiology Springer-Verlag 32/2(2011-02-01), 145-153 0172-0643 32:2<145 2011 32 246 https://doi.org/10.1007/s00246-010-9833-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9833-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cumbermack Kristopher Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Cheng Jun Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Nong Yibing Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Mahle William Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Joyner Ronald Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Border William Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Wagner Mary Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Fyfe Derek Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Leong Traci Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Wang Yanggan Department of Pediatrics, Children's Healthcare of Atlanta and Sibley Heart Center, Emory School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/2(2011-02-01), 145-153 0172-0643 32:2<145 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer