caa a22 4500 445826274 CHVBK 20180317145300.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00246-010-9839-x doi (NATIONALLICENCE)springer-10.1007/s00246-010-9839-x Low Renal Oximetry Correlates With Acute Kidney Injury After Infant Cardiac Surgery [Elektronische Daten] [Gabe Owens, Karen King, James Gurney, John Charpie] Acute kidney injury (AKI) is a frequent complication after cardiopulmonary bypass surgery during infancy. Standard methods for evaluating renal function are not particularly sensitive nor are proximate indicators of renal dysfunction that allow intervention in real time. Near-infrared spectroscopy (NIRS) is a newer noninvasive technology that continuously evaluates regional oximetry and may correlate with renal injury and adverse outcomes after cardiac surgery in infants. This prospective observational study enrolled 40 infants (age, <12months) undergoing biventricular repair. Continuous renal oximetry data were collected for the first 48 postoperative hours and correlated with postoperative course, standard laboratory data, and the occurrence of acute renal injury. Subjects with low renal oximetry (below 50% for >2h) had significantly higher postoperative peak creatinine levels by 48h (0.8±0.4 vs. 0.52±0.2; p=0.003) and a higher incidence of AKI (50 vs. 3.1%; p=0.003) than those with normal renal oximetry. These subjects also required more ventilator days and greater vasoactive support, and they had elevated lactate levels. Prolonged low renal near-infrared oximetry appears to correlate with renal dysfunction, decreased systemic oxygen delivery, and the overall postoperative course in infants with congenital heart disease undergoing biventricular repair. Springer Science+Business Media, LLC, 2010 AKI nationallicence Congenital heart nationallicence Regional oximetry nationallicence Owens Gabe Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan, 1500 East Medical Center Drive, 48109-5204, Ann Arbor, MI, USA aut King Karen Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan, 1500 East Medical Center Drive, 48109-5204, Ann Arbor, MI, USA aut Gurney James Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan, 1500 East Medical Center Drive, 48109-5204, Ann Arbor, MI, USA aut Charpie John Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan, 1500 East Medical Center Drive, 48109-5204, Ann Arbor, MI, USA aut Pediatric Cardiology Springer-Verlag 32/2(2011-02-01), 183-188 0172-0643 32:2<183 2011 32 246 https://doi.org/10.1007/s00246-010-9839-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9839-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Owens Gabe Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan, 1500 East Medical Center Drive, 48109-5204, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- King Karen Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan, 1500 East Medical Center Drive, 48109-5204, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Gurney James Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan, 1500 East Medical Center Drive, 48109-5204, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Charpie John Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan, 1500 East Medical Center Drive, 48109-5204, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/2(2011-02-01), 183-188 0172-0643 32:2<183 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer