caa a22 4500 445831944 CHVBK 20180317145318.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00586-011-1776-8 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1776-8 Abnormal activation of the motor cortical network in idiopathic scoliosis demonstrated by functional MRI [Elektronische Daten] [Julio Domenech, G. García-Martí, L. Martí-Bonmatí, C. Barrios, J. Tormos, A. Pascual-Leone] The aetiology of idiopathic scoliosis (IS) remains unknown, but there is growing support for the possibility of an underlying neurological disorder. Functional magnetic resonance imaging (fMRI) can characterize the abnormal activation of the sensorimotor brain network in movement disorders and could provide further insights into the neuropathogenesis of IS. Twenty subjects were included in the study; 10 adolescents with IS (mean age of 15.2, 8 girls and 2 boys) and 10 age-matched healthy controls. The average Cobb angle of the primary curve in the IS patients was 35° (range 27°-55°). All participants underwent a block-design fMRI experiment in a 1.5-Tesla MRI scanner to explore cortical activation following a simple motor task. Rest periods alternated with activation periods during which participants were required to open and close their hand at an internally paced rate of approximately 1Hz. Data were analyzed with Statistical Parametric Mapping (SPM5) including age, sex and laterality as nuisance variables to minimise the presence of bias in the results. Compared to controls, IS patients showed significant increases in blood oxygenation level dependent (BOLD) activity in contralateral supplementary motor area when performing the motor task with either hand. No significant differences were observed when testing between groups in the functional activation in the primary motor cortex, premotor cortex and somatosensory cortex. Additionally, the IS group showed a greater interhemispheric asymmetry index than the control group (0.30 vs. 0.13, p<0.001). This study demonstrates an abnormal pattern of brain activation in secondary motor areas during movement execution in patients with IS. These findings support the hypothesis that a sensorimotor integration disorder underlies the pathogenesis of IS. Springer-Verlag, 2011 Idiopathic scoliosis nationallicence Functional magnetic resonance imaging nationallicence Aetiology nationallicence Sensorimotor cortex nationallicence Domenech Julio Orthopedic Surgery Department, Hospital Arnau de Vilanova, Valencia, Spain aut García-Martí G. Department of Radiology, Quirón Hospital, Avda. Blasco Ibáñez, 14, 46010, Valencia, Spain aut Martí-Bonmatí L. Department of Radiology, Quirón Hospital, Avda. Blasco Ibáñez, 14, 46010, Valencia, Spain aut Barrios C. Institute for Research on Musculoskeletal Disorders, Valencia Catholic University, Valencia, Spain aut Tormos J. Insitut Universitari de Neurorehabilitació Guttmann-UAB, Badalona, Spain aut Pascual-Leone A. Insitut Universitari de Neurorehabilitació Guttmann-UAB, Badalona, Spain aut European Spine Journal Springer-Verlag 20/7(2011-07-01), 1069-1078 0940-6719 20:7<1069 2011 20 586 https://doi.org/10.1007/s00586-011-1776-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1776-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Domenech Julio Orthopedic Surgery Department, Hospital Arnau de Vilanova, Valencia, Spain aut NATIONALLICENCE 700 1- García-Martí G. Department of Radiology, Quirón Hospital, Avda. Blasco Ibáñez, 14, 46010, Valencia, Spain aut NATIONALLICENCE 700 1- Martí-Bonmatí L. Department of Radiology, Quirón Hospital, Avda. Blasco Ibáñez, 14, 46010, Valencia, Spain aut NATIONALLICENCE 700 1- Barrios C. Institute for Research on Musculoskeletal Disorders, Valencia Catholic University, Valencia, Spain aut NATIONALLICENCE 700 1- Tormos J. Insitut Universitari de Neurorehabilitació Guttmann-UAB, Badalona, Spain aut NATIONALLICENCE 700 1- Pascual-Leone A. Insitut Universitari de Neurorehabilitació Guttmann-UAB, Badalona, Spain aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/7(2011-07-01), 1069-1078 0940-6719 20:7<1069 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer