caa a22 4500 445832444 CHVBK 20180317145319.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00586-011-1796-4 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1796-4 Low pressure pain thresholds are associated with, but does not predispose for, low back pain [Elektronische Daten] [Søren O'Neill, Per Kjær, Thomas Graven-Nielsen, Claus Manniche, Lars Arendt-Nielsen] Chronic pain is often associated with hyperalgesia in cross-sectional studies. In the present study, a random cohort of 40-year-old individuals (n=264) from the general population was assessed for low back pain (LBP) status and pressure pain threshold (PPT), with follow-up assessment 4 and 8years later. Low PPT at baseline as a potential risk factor for the development of LBP was investigated longitudinally and the association between LBP and hyperalgesia was studied cross-sectionally at baseline and 8-year follow-up. Generalized (p <0.03) and localized pressure hyperalgesia (p<0.02) was found in participants with long-lasting LBP, but not with recent LBP (p>0.08). Of the participants without recent or long-lasting LBP, those with a low PPT at baseline (lower 10% percentile) had no increased risk of developing LBP (p>0.05). The findings indicate that PPT decreases as a consequence of long-lasting pain, whereas a low PPT seems not to constitute a separate risk factor for the development of LBP. Springer-Verlag, 2011 Low back pain nationallicence Generalized hyperalgesia nationallicence Quantitative sensory testing nationallicence Central sensitization nationallicence Pressure pain threshold nationallicence O'Neill Søren Spine Centre of Southern Denmark, Lillebælt Hospital, Institute of Regional Health Services Research, Clinical Locomotion Science Network, University of Southern Denmark, Østre Hougvej 55, 5500, Middelfart, Denmark aut Kjær Per Spine Centre of Southern Denmark, Lillebælt Hospital, Institute of Regional Health Services Research, Clinical Locomotion Science Network, University of Southern Denmark, Østre Hougvej 55, 5500, Middelfart, Denmark aut Graven-Nielsen Thomas Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D3, 9220, Aalborg, Denmark aut Manniche Claus Spine Centre of Southern Denmark, Lillebælt Hospital, Institute of Regional Health Services Research, Clinical Locomotion Science Network, University of Southern Denmark, Østre Hougvej 55, 5500, Middelfart, Denmark aut Arendt-Nielsen Lars Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D3, 9220, Aalborg, Denmark aut European Spine Journal Springer-Verlag 20/12(2011-12-01), 2120-2125 0940-6719 20:12<2120 2011 20 586 https://doi.org/10.1007/s00586-011-1796-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1796-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- O'Neill Søren Spine Centre of Southern Denmark, Lillebælt Hospital, Institute of Regional Health Services Research, Clinical Locomotion Science Network, University of Southern Denmark, Østre Hougvej 55, 5500, Middelfart, Denmark aut NATIONALLICENCE 700 1- Kjær Per Spine Centre of Southern Denmark, Lillebælt Hospital, Institute of Regional Health Services Research, Clinical Locomotion Science Network, University of Southern Denmark, Østre Hougvej 55, 5500, Middelfart, Denmark aut NATIONALLICENCE 700 1- Graven-Nielsen Thomas Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D3, 9220, Aalborg, Denmark aut NATIONALLICENCE 700 1- Manniche Claus Spine Centre of Southern Denmark, Lillebælt Hospital, Institute of Regional Health Services Research, Clinical Locomotion Science Network, University of Southern Denmark, Østre Hougvej 55, 5500, Middelfart, Denmark aut NATIONALLICENCE 700 1- Arendt-Nielsen Lars Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D3, 9220, Aalborg, Denmark aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/12(2011-12-01), 2120-2125 0940-6719 20:12<2120 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer