caa a22 4500 445833025 CHVBK 20180317145321.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00586-011-1737-2 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1737-2 Symptomatic disc herniation and serum lipid levels [Elektronische Daten] [Umile Longo, Luca Denaro, Filippo Spiezia, Francisco Forriol, Nicola Maffulli, Vincenzo Denaro] Insufficient blood supply to the intervertebral disc (IVD) has been proposed to play a role as causative factor in IVD degeneration. There is an association between IVD diseases and increased risk of dying of ischaemic heart disease. Obesity and tobacco are potential risk factors for degenerative IVD disease. High blood cholesterol and triglycerides serum levels are risk factors for atherosclerosis, and could be responsible for a decreased in the blood supply to the already poor vascularized IVD. We performed a frequency-matched case-control study to determine the serum levels of patients with symptomatic herniated lumbar disc. We examined the fasting serum lipid levels in 384 subjects who were operated at our institution. Group 1 included 169 consecutive patients (115 men and 54 women; mean age: 59.1years, range 29-85) who underwent surgery for symptomatic disc herniation. Group 2 (control group) included 169 patients (115 men and 54 women; mean age: 61years, range 26-86) who underwent arthroscopic meniscectomy for a meniscal tear in the same period. These patients were frequency-matched by age (within 3years) and gender with patients of Group 1. Sera were extracted from blood samples and the concentrations of total cholesterol (TC) and triglycerides (TG) were determined. When comparing the two groups, patients with symptomatic herniated lumbar disc showed statistically significant higher triglyceride concentration (P=0.02) and total cholesterol concentration (P=0.01). Serum lipid levels may be a risk factor for IVD pathology. An enhanced understanding of these factors holds the promise of new approaches to the prevention and management of IVD pathology. Springer-Verlag, 2011 Intervertebral disc nationallicence Serum lipids nationallicence Cholesterol nationallicence Triglycerides nationallicence Degeneration nationallicence Longo Umile Department of Orthopaedic and Trauma Surgery, Campus Biomedico University, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut Denaro Luca Department of Neuroscience, University of Padua, Via Giustiniani, 5, 35128, Padua, Italy aut Spiezia Filippo Department of Orthopaedic and Trauma Surgery, Campus Biomedico University, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut Forriol Francisco Department of Orthopaedic Surgery, University CEU, Madrid, Spain aut Maffulli Nicola Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, E1 4DG, London, UK aut Denaro Vincenzo Department of Orthopaedic and Trauma Surgery, Campus Biomedico University, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut European Spine Journal Springer-Verlag 20/10(2011-10-01), 1658-1662 0940-6719 20:10<1658 2011 20 586 https://doi.org/10.1007/s00586-011-1737-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1737-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Longo Umile Department of Orthopaedic and Trauma Surgery, Campus Biomedico University, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut NATIONALLICENCE 700 1- Denaro Luca Department of Neuroscience, University of Padua, Via Giustiniani, 5, 35128, Padua, Italy aut NATIONALLICENCE 700 1- Spiezia Filippo Department of Orthopaedic and Trauma Surgery, Campus Biomedico University, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut NATIONALLICENCE 700 1- Forriol Francisco Department of Orthopaedic Surgery, University CEU, Madrid, Spain aut NATIONALLICENCE 700 1- Maffulli Nicola Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, E1 4DG, London, UK aut NATIONALLICENCE 700 1- Denaro Vincenzo Department of Orthopaedic and Trauma Surgery, Campus Biomedico University, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/10(2011-10-01), 1658-1662 0940-6719 20:10<1658 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer