caa a22 4500 445833211 CHVBK 20180317145322.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00586-011-1750-5 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1750-5 The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis (AIS) [Elektronische Daten] [M. Girardo, N. Bettini, E. Dema, S. Cervellati] The cause of adolescent idiopathic scoliosis (AIS) in humans remains obscure and probably multifactorial. At present, there is no proven method or test available to identify children or adolescent at risk of developing AIS or identify which of the affected individuals are at risk of progression. Reported associations are linked in pathogenesis rather than etiologic factors. Melatonin may play a role in the pathogenesis of scoliosis (neuroendocrine hypothesis), but at present, the data available cannot clearly show the role of melatonin in producing scoliosis in humans. The data regarding human melatonin levels are mixed at best, and the melatonin deficiency as a causative factor in the etiology of scoliosis cannot be supported. It will be an important issue of future research to investigate the role of melatonin in human biology, the clinical efficacy, and safety of melatonin under different pathological situations. Research is needed to better define the role of all factors in AIS development. The Author(s), 2011 Scoliosis nationallicence Melatonin nationallicence Chicken nationallicence Melatonin receptor nationallicence Pineal gland nationallicence Girardo M. Department of Spine Surgery, C.T.O./C.R.F./Maria Adelaide, Via Zuretti 29, 10126, Turin, Italy aut Bettini N. Scoliosis and Spine Surgery Center, Hesperia Hospital, Via Arquà 80/A, 41100, Modena, Italy aut Dema E. Scoliosis and Spine Surgery Center, Hesperia Hospital, Via Arquà 80/A, 41100, Modena, Italy aut Cervellati S. Scoliosis and Spine Surgery Center, Hesperia Hospital, Via Arquà 80/A, 41100, Modena, Italy aut European Spine Journal Springer-Verlag 20(2011-05-01), 68-74 0940-6719 20<68 2011 20 586 https://doi.org/10.1007/s00586-011-1750-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1750-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Girardo M. Department of Spine Surgery, C.T.O./C.R.F./Maria Adelaide, Via Zuretti 29, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Bettini N. Scoliosis and Spine Surgery Center, Hesperia Hospital, Via Arquà 80/A, 41100, Modena, Italy aut NATIONALLICENCE 700 1- Dema E. Scoliosis and Spine Surgery Center, Hesperia Hospital, Via Arquà 80/A, 41100, Modena, Italy aut NATIONALLICENCE 700 1- Cervellati S. Scoliosis and Spine Surgery Center, Hesperia Hospital, Via Arquà 80/A, 41100, Modena, Italy aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20(2011-05-01), 68-74 0940-6719 20<68 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer