caa a22 4500 445833785 CHVBK 20180317145324.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00586-010-1586-4 doi (NATIONALLICENCE)springer-10.1007/s00586-010-1586-4 The mechanical response of the lumbar spine to different combinations of disc degenerative changes investigated using randomized poroelastic finite element models [Elektronische Daten] [Fabio Galbusera, Hendrik Schmidt, Cornelia Neidlinger-Wilke, Andreas Gottschalk, Hans-Joachim Wilke] Degeneration of the intervertebral disc is related to progressive changes in the disc tissue composition and morphology, such as water loss, disc height loss, endplate calcification, osteophytosis. These changes may be present separately or, more frequently, in various combinations. This work is aimed to the biomechanical investigation of a wide range of clinical scenarios of disc degeneration, in which the most common degenerative changes are present in various combinations. A poroelastic non-linear finite element model of the healthy L4-L5 human spine segment was employed and randomly scaled to represent ten spine segments from different individuals. Six different degenerative characteristics (water loss in the nucleus pulposus and annulus fibrosus; calcification and thickness reduction of endplate cartilage; disc height loss; osteophyte formation; diffuse sclerosis) were modeled in 30 randomly generated models, 10 for each overall degree of degeneration (mild, moderate, severe). For each model, a daily loading cycle including 8h of rest, 16h in the standing position with superimposed two flexion-extension motion cycles was simulated. A tendency to an increase of stiffness with progressing overall degeneration was observed, in compression, flexion and extension. Hence, instability for mild degeneration was not predicted. Facet forces and fluid loss decreased with disc degeneration. Nucleus, annulus and endplate degeneration, disc height loss, osteophytosis and diffuse sclerosis all induced a statistically significant decrease in the total daily disc height variation, facet force and flexibility in flexion-extension. Therefore, grading systems for disc degeneration should include all the degenerative changes considered in this work, since all of them had a significant influence on the spinal biomechanics. Springer-Verlag, 2010 Disc degeneration nationallicence Lumbar nationallicence Morphological changes nationallicence Finite element nationallicence Poroelastic nationallicence Random nationallicence Galbusera Fabio Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081, Ulm, Germany aut Schmidt Hendrik Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081, Ulm, Germany aut Neidlinger-Wilke Cornelia Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081, Ulm, Germany aut Gottschalk Andreas Department of Radiology, Bunderwehrkrankenhaus, Ulm, Germany aut Wilke Hans-Joachim Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081, Ulm, Germany aut European Spine Journal Springer-Verlag 20/4(2011-04-01), 563-571 0940-6719 20:4<563 2011 20 586 https://doi.org/10.1007/s00586-010-1586-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-010-1586-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Galbusera Fabio Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081, Ulm, Germany aut NATIONALLICENCE 700 1- Schmidt Hendrik Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081, Ulm, Germany aut NATIONALLICENCE 700 1- Neidlinger-Wilke Cornelia Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081, Ulm, Germany aut NATIONALLICENCE 700 1- Gottschalk Andreas Department of Radiology, Bunderwehrkrankenhaus, Ulm, Germany aut NATIONALLICENCE 700 1- Wilke Hans-Joachim Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081, Ulm, Germany aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/4(2011-04-01), 563-571 0940-6719 20:4<563 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer