caa a22 4500 445833955 CHVBK 20180317145324.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00586-010-1663-8 doi (NATIONALLICENCE)springer-10.1007/s00586-010-1663-8 Clinical significance of cerebrospinal fluid nitric oxide concentrations in degenerative cervical and lumbar diseases [Elektronische Daten] [Hiroshi Denda, Shinji Kimura, Akiyoshi Yamazaki, Noboru Hosaka, Yuichi Takano, Kenji Imura, Yoichi Yajiri, Naoto Endo] In animal models of degenerative lumbar disease, inducible nitric oxide synthase (iNOS) is expressed in macrophages and Schwann cells following compression of the cauda equina. We previously reported that NO metabolites (nitrite plus nitrate: [NOx]) in the cerebrospinal fluid (CSF) correlate with postoperative pain relief in patients with degenerative lumbar disease and with neurologic recovery rate postoperatively or after conservative treatment in patients with spinal cord injury. The objective of the present study was to examine the relationship between [NOx] and neurologic severity, and recovery in degenerative cervical and lumbar diseases. Two hundred fifty-seven cases, including 85 patients with cervical compression myelopathy (CCM), 25 with cervical disc herniation (CDH), 70 with lumbar canal stenosis (LCS), and 77 with lumbar disc herniation (LDH), were examined. The CSF [NOx] was measured using the Griess method. Severity of neurologic impairment and clinical recovery was assessed using the Japanese Orthopedic Association score and Hirabayashi's method. [NOx] in CCM and LCS, but not CDH and LDH groups, was significantly higher than that in controls, and correlated with postoperative recovery rates, but not with preoperative neurologic severity. [NOx] significantly correlated with neurologic recovery following surgery for CCM and LCS. Springer-Verlag, 2010 Nitric oxide nationallicence Degenerative cervical diseases nationallicence Degenerative lumbar diseases nationallicence Cerebrospinal fluid nationallicence Neurologic severity nationallicence Neurologic recovery nationallicence Denda Hiroshi Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, 951-8510, Niigata, Japan aut Kimura Shinji Rehabilitation Center, Niigata University Medical and Dental Hospital, Asahimachi-dori 1-754, 951-8520, Niigata, Japan aut Yamazaki Akiyoshi Department of Orthopedic Surgery, Spine Center, Niigata Central Hospital, Shinko-cho 1-18, Chuo-ku, 950-8556, Niigata, Japan aut Hosaka Noboru Department of Orthopedic Surgery, Niigata Rosai Hospital, Toun-cho 1-7-12, Joetsu-shi, 942-8502, Niigata, Japan aut Takano Yuichi Department of Orthopedic Surgery, Akita Red Cross Hospital, Inawashirosawa 222-1, 010-8502, Akita-shi Akita, Japan aut Imura Kenji Department of Orthopedic Surgery, Nagaoka Red Cross Hospital, Senshu 2-297-1, Nagaoka-shi, 940-2085, Niigata, Japan aut Yajiri Yoichi Department of Orthopedic Surgery, Nagaoka Central Hospital, Kawasaki 2041, Nagaoka-shi, 940-8653, Niigata, Japan aut Endo Naoto Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, 951-8510, Niigata, Japan aut European Spine Journal Springer-Verlag 20/4(2011-04-01), 604-611 0940-6719 20:4<604 2011 20 586 https://doi.org/10.1007/s00586-010-1663-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-010-1663-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Denda Hiroshi Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, 951-8510, Niigata, Japan aut NATIONALLICENCE 700 1- Kimura Shinji Rehabilitation Center, Niigata University Medical and Dental Hospital, Asahimachi-dori 1-754, 951-8520, Niigata, Japan aut NATIONALLICENCE 700 1- Yamazaki Akiyoshi Department of Orthopedic Surgery, Spine Center, Niigata Central Hospital, Shinko-cho 1-18, Chuo-ku, 950-8556, Niigata, Japan aut NATIONALLICENCE 700 1- Hosaka Noboru Department of Orthopedic Surgery, Niigata Rosai Hospital, Toun-cho 1-7-12, Joetsu-shi, 942-8502, Niigata, Japan aut NATIONALLICENCE 700 1- Takano Yuichi Department of Orthopedic Surgery, Akita Red Cross Hospital, Inawashirosawa 222-1, 010-8502, Akita-shi Akita, Japan aut NATIONALLICENCE 700 1- Imura Kenji Department of Orthopedic Surgery, Nagaoka Red Cross Hospital, Senshu 2-297-1, Nagaoka-shi, 940-2085, Niigata, Japan aut NATIONALLICENCE 700 1- Yajiri Yoichi Department of Orthopedic Surgery, Nagaoka Central Hospital, Kawasaki 2041, Nagaoka-shi, 940-8653, Niigata, Japan aut NATIONALLICENCE 700 1- Endo Naoto Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, 951-8510, Niigata, Japan aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/4(2011-04-01), 604-611 0940-6719 20:4<604 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer