caa a22 4500 445834021 CHVBK 20180317145324.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00586-011-1706-9 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1706-9 Evaluation of tenoxicam on prevention of arachnoiditis in rat laminectomy model [Elektronische Daten] [Berker Cemil, Gokhan Kurt, Cansel Aydın, Nalan Akyurek, Bulent Erdogan, Necdet Ceviker] Post laminectomy arachnoiditis has been shown by experiments with rats and post operative radiological imaging in humans. The purpose of this experimental study was to determine the efficacy of tenoxicam in preventing arachnoiditis in rats. Twenty-four Wistar rats were divided into two groups, and L3 laminectomy was performed. In the tenoxicam group, 0.5mg/kg tenoxicam was applied intraperitoneally. Normal saline was applied intraperitoneally in the control group. Later, the rats were killed at weeks 3 and 6, and the laminectomy sites were evaluated pathologically for arachnoiditis. The results showed that 6weeks after surgery, the tenoxicam group showed lowest arachnoiditis grades. However, statistically significant difference was not found in arachnoiditis between the control group and the tenoxicam group. Based on these findings it is concluded that application of the tenoxicam after lumbar laminectomy did not effectively reduce arachnoiditis. Performing the most effective surgical technique without damage around tissue in a small surgical wound and having meticulous hemostasis in surgery seem to be the key for preventing arachnoiditis effectively. Springer-Verlag, 2011 Arachnoiditis nationallicence Laminectomy nationallicence Non-steroidal anti-inflammatory drugs nationallicence Tenoxicam nationallicence Cemil Berker Department of Neurosurgery, Fatih University Faculty of Medicine, 06510, Bestepeler, Ankara, Turkey aut Kurt Gokhan Department of Neurosurgery, Gazi University Faculty of Medicine, 06500, Besevler, Ankara, Turkey aut Aydın Cansel Department of Neurosurgery, Gazi University Faculty of Medicine, 06500, Besevler, Ankara, Turkey aut Akyurek Nalan Department of Pathology, Gazi University Faculty of Medicine, 06500, Besevler, Ankara, Turkey aut Erdogan Bulent Department of Neurosurgery, Fatih University Faculty of Medicine, 06510, Bestepeler, Ankara, Turkey aut Ceviker Necdet Department of Neurosurgery, Gazi University Faculty of Medicine, 06500, Besevler, Ankara, Turkey aut European Spine Journal Springer-Verlag 20/8(2011-08-01), 1255-1258 0940-6719 20:8<1255 2011 20 586 https://doi.org/10.1007/s00586-011-1706-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1706-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cemil Berker Department of Neurosurgery, Fatih University Faculty of Medicine, 06510, Bestepeler, Ankara, Turkey aut NATIONALLICENCE 700 1- Kurt Gokhan Department of Neurosurgery, Gazi University Faculty of Medicine, 06500, Besevler, Ankara, Turkey aut NATIONALLICENCE 700 1- Aydın Cansel Department of Neurosurgery, Gazi University Faculty of Medicine, 06500, Besevler, Ankara, Turkey aut NATIONALLICENCE 700 1- Akyurek Nalan Department of Pathology, Gazi University Faculty of Medicine, 06500, Besevler, Ankara, Turkey aut NATIONALLICENCE 700 1- Erdogan Bulent Department of Neurosurgery, Fatih University Faculty of Medicine, 06510, Bestepeler, Ankara, Turkey aut NATIONALLICENCE 700 1- Ceviker Necdet Department of Neurosurgery, Gazi University Faculty of Medicine, 06500, Besevler, Ankara, Turkey aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/8(2011-08-01), 1255-1258 0940-6719 20:8<1255 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer