caa a22 4500 445834064 CHVBK 20180317145325.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00586-011-1697-6 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1697-6 Long-term reduction in pain and disability after surgery with the interspinous device for intervertebral assisted motion (DIAM) spinal stabilization system in patients with low back pain: 4-year follow-up from a longitudinal prospective case series [Elektronische Daten] [Josip Buric, Massimiliano Pulidori] Patients with low back pain (LBP) suffer chronic disability. In 40% of LBP patients degenerative disc disease (DDD) seems to be the cause. This prospective case series assessed the efficacy of the interspinous device for intervertebral assisted motion (DIAM™) in patients with LBP resulting from DDD. All patients were initially assessed by physical examinations, magnetic resonance imaging, dynamic X-rays and provocative discography. Eligible patients (n=52) had LBP for a minimum of 4months, and received surgery with the DIAM™ system 2-4weeks after diagnosis. Patients were evaluated pre-/post-operatively for pain severity using a visual analogue scale (VAS), and for dysfunction and disability with the Roland-Morris Disability Questionnaire (RMDQ). VAS and RMDQ score changes were assessed using the appropriate contrasts and Bonferroni-corrected P values. As a result, significant (P<0.0001) pain score reductions were observed between baseline values, and 2 (3.7, 95% CI 3.1; 4.2) and 48 (3.1, 95% CI 2.5; 3.6) months follow-up (intent-to-treat population). Disability scores were significantly (P<0.0001) reduced between baseline and 2 (8.6, 95% CI 7.4; 9.9) and 48 (7.5, 95% CI 6.1; 8.9) months. Disability scores were similar from months 2 to 48. At 48months, 67.3% of patients reached the minimum clinically important difference (MCID; ≥1.5-unit improvement) in VAS score and 78.9% of patients reached the MCID (≥30% improvement) in RMDQ score. No complications were associated with surgery. In conclusion, patients with LBP treated with the interspinous DIAM™ system showed significant and clinically meaningful improvements in pain and disability for up to 4years. Springer-Verlag, 2011 Degenerative disc disease nationallicence DIAM nationallicence Interspinous device nationallicence Low back pain nationallicence Minimally invasive treatment nationallicence Pain reduction nationallicence Buric Josip Unita Funzionale di Chirurgia Spinale c.d.c. Villanova, Florence, Italy aut Pulidori Massimiliano Unita Funzionale di Chirurgia Spinale c.d.c. Villanova, Florence, Italy aut European Spine Journal Springer-Verlag 20/8(2011-08-01), 1304-1311 0940-6719 20:8<1304 2011 20 586 https://doi.org/10.1007/s00586-011-1697-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1697-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Buric Josip Unita Funzionale di Chirurgia Spinale c.d.c. Villanova, Florence, Italy aut NATIONALLICENCE 700 1- Pulidori Massimiliano Unita Funzionale di Chirurgia Spinale c.d.c. Villanova, Florence, Italy aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/8(2011-08-01), 1304-1311 0940-6719 20:8<1304 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer