caa a22 4500 445834129 CHVBK 20180317145325.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00586-011-1794-6 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1794-6 The prevalence of MRI-defined spinal pathoanatomies and their association with Modic changes in individuals seeking care for low back pain [Elektronische Daten] [Hanne Albert, Andrew Briggs, Peter Kent, Andreas Byrhagen, Christian Hansen, Karina Kjaergaard] Modic changes are of increasing interest, however their age and gender prevalence are not well described. To date, the associations between Modic changes and other common vertebral pathologies have only been described in small samples (n<100). Our aim was, in a large dataset of people with low back pain, to (1) describe the prevalence of a range of spinal pathoanatomies, and (2) examine the association between Modic changes and stages of intervertebral disc (IVD) pathology. Common pathologies were coded from the lumbar spine MRIs from 4,233 consecutive people imaged while attending a publicly-funded secondary care outpatient facility in Denmark. Prevalence data were calculated by pathology and by vertebral level. Prevalence was also calculated by age and gender categories for Modic changes. The association between stages of IVD pathology (degeneration, bulge, herniation) and Modic changes at L4/5 and L5/S1 was expressed using prevalence ratios (PR) and 95% confidence intervals. The prevalence of Modic changes and IVD pathology were greater in L4/5 and L5/S1, compared with the upper lumbar spine. There was no significant gender difference in prevalence of Modic changes (p=0.11). The prevalence of IVD disc pathology occurring concurrently with Modic changes ranged from 11.5 to 17.5% (Type 1), 8.5 to 12.7% (Type 2) and 17.1 to 25.6% (Type 1 and/or 2) while the prevalence occurring in the absence of Modic changes ranged from 0.5 to 6.3% (Type 1), 0.3 to 4.9 (Type 2), 0.8 to 9.7% (Type 1 and/or 2). The associated PR for IVD pathology occurring concurrently with Modic changes ranged from 1.8 to 29.2 (p<0.05). The highest PR (29.2) was between degeneration and Modic changes, indicating that it is rare for Modic changes to occur without disc degeneration. Spinal pathoanatomy was common in this population, particularly IVD pathologies, and a consistent trend of a relatively greater prevalence in the lower lumbar spine was identified. Modic changes were more likely to be present among individuals with IVD pathology than without, which may implicate mechanical factors as being one aetiological pathway for Modic changes, although other hypotheses may equally explain this association. Springer-Verlag, 2011 Modic changes nationallicence Prevalence nationallicence Spine pathology nationallicence Low back pain nationallicence IVD pathology nationallicence Albert Hanne Research Department, Spine Centre of Southern Denmark, Lillebaelt Hospital, Oestre Hougvej 55, 5500, Middelfart, Denmark aut Briggs Andrew School of Physiotherapy and Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, Australia aut Kent Peter Research Department, Spine Centre of Southern Denmark, Lillebaelt Hospital, Oestre Hougvej 55, 5500, Middelfart, Denmark aut Byrhagen Andreas Department of Physiotherapy, University College Lillebælt, Odense, Denmark aut Hansen Christian Department of Physiotherapy, University College Lillebælt, Odense, Denmark aut Kjaergaard Karina Department of Physiotherapy, University College Lillebælt, Odense, Denmark aut European Spine Journal Springer-Verlag 20/8(2011-08-01), 1355-1362 0940-6719 20:8<1355 2011 20 586 https://doi.org/10.1007/s00586-011-1794-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1794-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Albert Hanne Research Department, Spine Centre of Southern Denmark, Lillebaelt Hospital, Oestre Hougvej 55, 5500, Middelfart, Denmark aut NATIONALLICENCE 700 1- Briggs Andrew School of Physiotherapy and Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, Australia aut NATIONALLICENCE 700 1- Kent Peter Research Department, Spine Centre of Southern Denmark, Lillebaelt Hospital, Oestre Hougvej 55, 5500, Middelfart, Denmark aut NATIONALLICENCE 700 1- Byrhagen Andreas Department of Physiotherapy, University College Lillebælt, Odense, Denmark aut NATIONALLICENCE 700 1- Hansen Christian Department of Physiotherapy, University College Lillebælt, Odense, Denmark aut NATIONALLICENCE 700 1- Kjaergaard Karina Department of Physiotherapy, University College Lillebælt, Odense, Denmark aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/8(2011-08-01), 1355-1362 0940-6719 20:8<1355 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer