caa a22 4500 445834668 CHVBK 20180317145326.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00586-011-1905-4 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1905-4 Biomechanical, histological and histomorphometric analyses of calcium phosphate cement compared to PMMA for vertebral augmentation in a validated animal model [Elektronische Daten] [Luis Galovich, Antonio Perez-Higueras, Jose Altonaga, José Gonzalo Orden, Maria Mariñoso Barba, Maria Carrascal Morillo] Introduction: Calcium phosphate cements (biocements) are alternative materials for use in vertebral augmentation procedures, and are a potential solution to problems associated with polymethylmethacrylate (PMMA) cements. The aim of this study is to demonstrate the utility of percutaneously injected biocements compared with PMMA in a validated animal model of osteoporosis. Materials and methods: Fortyseven augmentation procedures were performed on 11 osteoporotic sheep. 9 vertebrae were augmented with PMMA and 38 with a biocement. The animals were killed in four groups: at 7days, 3months, 6months, and 1year after intervention. Radiological study and TC of the pieces were obtained to evaluate for leakage, cement diffusion, and integration. In total, 26 biomechanic studies and 27 histomorphometry analyses were performed, included control vertebrae. Results: In 20.9% of the vertebrae, the hole was empty at sacrifice. The pattern of fracture was heterogeneous, and cement augmentation did not increase vertebral strength or decrease vertebral stiffness compared to control vertebrae, with neither PMMA or biocement. The rate of remodeling of the biocement was not predictable. In the single majority, there is peripheral remodeling, staying the volume of injected biocement stable. Conclusions: Even though this animal model may not be useful to analyze the biomechanical pattern of treated vertebrae, it demonstrates that the percutaneous use of biocements in vertebral augmentation techniques is not predictable. This is one reason not to recommend its use presently as a substitute for PMMA in vertebral reinforcement procedures. Springer-Verlag, 2011 Biocements nationallicence CaP cement nationallicence Vertebroplasty nationallicence Osteoporosis nationallicence Kyphoplasty nationallicence Galovich Luis Spine Service, Fundación Jiménez DÍaz, Av Reyes Católicos, 2, 28040, Madrid, Spain aut Perez-Higueras Antonio Neuroradiology Service, Fundación Jiménez DÍaz, Av Reyes Católicos, 2, 28040, Madrid, Spain aut Altonaga Jose Facultad de Veterinaria, Universidad de León, León, Spain aut Gonzalo Orden José Facultad de Veterinaria, Universidad de León, León, Spain aut Mariñoso Barba Maria Laboratorio de Anatomía Patológica y Biología Molecular, Hospital del Mar, Barcelona, Spain aut Carrascal Morillo Maria Departamento de Mecánica, E.T.S.Ingenieros Industriales, UNED, Madrid, Spain aut European Spine Journal Springer-Verlag 20(2011-08-01), 376-382 0940-6719 20<376 2011 20 586 https://doi.org/10.1007/s00586-011-1905-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1905-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Galovich Luis Spine Service, Fundación Jiménez DÍaz, Av Reyes Católicos, 2, 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Perez-Higueras Antonio Neuroradiology Service, Fundación Jiménez DÍaz, Av Reyes Católicos, 2, 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Altonaga Jose Facultad de Veterinaria, Universidad de León, León, Spain aut NATIONALLICENCE 700 1- Gonzalo Orden José Facultad de Veterinaria, Universidad de León, León, Spain aut NATIONALLICENCE 700 1- Mariñoso Barba Maria Laboratorio de Anatomía Patológica y Biología Molecular, Hospital del Mar, Barcelona, Spain aut NATIONALLICENCE 700 1- Carrascal Morillo Maria Departamento de Mecánica, E.T.S.Ingenieros Industriales, UNED, Madrid, Spain aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20(2011-08-01), 376-382 0940-6719 20<376 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer