caa a22 4500 445834692 CHVBK 20180317145327.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00586-011-1909-0 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1909-0 Vertebral growth modulation by hemicircumferential electrocoagulation: an experimental study in pigs [Elektronische Daten] [Alberto Caballero, Carlos Barrios, Jesús Burgos, Eduardo Hevia, Carlos Correa] Introduction: This experimental study in pigs was aimed at evaluating spinal growth disorders after partial arrest of the vertebral epiphyseal plates (EP) and neurocentral cartilages (NCC). Unilateral and multisegmental single or combined lesions of the physeal structures were performed by electrocogulation throughout a video-assisted thoracoscopical approach. Materials and methods: Thirty 4-week-old domestic pigs (mean weight 16kg) were included in the experiments. The superior and inferior epiphyseal plates of T5 to T9 vertebra were damaged in ten animals by hemicircumferential electrocoagulation (group I). In other ten pigs (group II), right NCC at the same T5-T9 levels were damaged. Ten other animals underwent combined lesions of the ipsilateral hemiepiphyseal plates and NCC at the T5-T9 levels. A total of 26 animals could be evaluated after 12weeks of follow-up using conventional X-rays, CT scans and histology. Results: The pigs with hemicircumferential EP damage developed very slight concave non-structured scoliotic deformities without vertebral rotation.(mean 12° Cobb; range10-16°). Some of the damaged vertebra showed a marked wedgening with unilateral development alteration of the vertebral body, including the adjacent discs The animals with damage of the NCC developed mild scoliotic curves (mean 19° Cobb; range 16-24°) with convexity opposite to the damaged side and loss of physiological kyphosis. The injured segments showed an asymmetric growth with hypoplasia of the pedicle and costovertebral joints at the damaged side. The pigs undergoing combined EP and NCC lesions developed minimal non-structured curves, ranging from 10 to 12° Cobb. In these animals there was a lack of growth of a vertebral hemibody and disc hypoplasia at the damaged segments. Both damage of the NCC and the EP affect the height of the vertebral body. No spinal stenosis was found in any case. In most cases, the adjacent superior and inferior vertebral EP to damaged segments had a compensatory growth that maintained the straight spinal shape. Conclusions: In summary, unilateral direct lesion of the EP by hemicircumferential thoracoscopic electrocoagulation modifies vertebral growth, but is not able to induce true scoliostic curves in pigs. Only animals with damaged NCC developed mild scoliotic curves of lordotic type. This work rediscovers and emphasizes the decisive role of the neurocentral cartilage in the ethiopatogeny of idiopathic scoliosis. Springer-Verlag, 2011 Experimental scoliosis nationallicence Epiphyseal vertebral plate nationallicence Neurocentral cartilage nationallicence Spinal growth nationallicence Caballero Alberto Spinal Surgery Unit, Hospital La Fraternidad, Paseo de la Habana 83-85, Madrid, Spain aut Barrios Carlos Orthopaedics and Trauma Unit, Department of Surgery, Valencia University Medical School, Valencia, Spain aut Burgos Jesús Division of Pediatric Orthopedics, Hospital Ramón y Cajal, Madrid, Spain aut Hevia Eduardo Spinal Surgery Unit, Hospital La Fraternidad, Paseo de la Habana 83-85, Madrid, Spain aut Correa Carlos Experimental Surgery Unit, Hospital Ramón y Cajal, Madrid, Spain aut European Spine Journal Springer-Verlag 20(2011-08-01), 367-375 0940-6719 20<367 2011 20 586 https://doi.org/10.1007/s00586-011-1909-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1909-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Caballero Alberto Spinal Surgery Unit, Hospital La Fraternidad, Paseo de la Habana 83-85, Madrid, Spain aut NATIONALLICENCE 700 1- Barrios Carlos Orthopaedics and Trauma Unit, Department of Surgery, Valencia University Medical School, Valencia, Spain aut NATIONALLICENCE 700 1- Burgos Jesús Division of Pediatric Orthopedics, Hospital Ramón y Cajal, Madrid, Spain aut NATIONALLICENCE 700 1- Hevia Eduardo Spinal Surgery Unit, Hospital La Fraternidad, Paseo de la Habana 83-85, Madrid, Spain aut NATIONALLICENCE 700 1- Correa Carlos Experimental Surgery Unit, Hospital Ramón y Cajal, Madrid, Spain aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20(2011-08-01), 367-375 0940-6719 20<367 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer