caa a22 4500 445834749 CHVBK 20180317145327.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00586-011-1915-2 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1915-2 The IL - 1 β (+3953 T/C) gene polymorphism associates to symptomatic lumbar disc herniation [Elektronische Daten] [J. Paz Aparicio, I. Fernández Bances, E. López-Anglada Fernández, A. Montes, A. Paz Aparicio, J. Pena Vázquez, S. Ramos García, S. Antón García, P. López Fernández, E. Valle-Garay, V. Asensi] Purpose: To determine whether polymorphisms (SNPs) in the genes encoding cytokines and nitric oxide synthase (NOS) might play some role in lumbar disc herniation (LDH). Patients and methods: Case-control study in which 179 patients were retrospectively reviewed. The case group was made of 50 patients with symptomatic LDH diagnosed by MRI while the control group was made of 129 individuals undergoing routine hip or knee arthroplasty with a lifetime lack of low back pain. SNPs in the cytokine genes of IL-1 [IL-1α (−889 C/T), IL-1β (+3953 T/C)], TNF-α (−308 G/A and −238 G/A) and NOS genes [eNOS (r 27bp, intron 4 and −786 T/C) and iNOS (22G/A)]. Results: The CC genotype and C allele of the IL-1β (+3953 T/C) SNP were significantly more frequent among LDH patients compared to controls. On the other hand, eNOS (−768 T/C) and iNOS (22G/A) SNPs were significantly more common in the control group. Conclusions: Carriers of the CC genotype of the IL-1β (+3953 T/C) SNP were more frequent among LDH patients suggesting some potential role of the IL-1β SNP on LDH pathogenesis. The eNOS (−786 T/C) and iNOS (22 G/A) SNPs were more frequent among the control subjects, suggesting their possible protective role against LDH. Genotyping these SNPs could be useful to identify persons with an increased lifetime risk of disc herniation in whom measures to avoid LDH could be implemented. Springer-Verlag, 2011 Lumbar disc herniation nationallicence Polymorphism nationallicence Cytokine nationallicence Nitric oxide synthase nationallicence Paz Aparicio J. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut Fernández Bances I. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut López-Anglada Fernández E. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut Montes A. Biochemistry and Molecular Biology, Oviedo University Medical School, Oviedo, Spain aut Paz Aparicio A. Anesthesiology and Critical Care, Hospital Universitario Central de Asturias, Oviedo, Spain aut Pena Vázquez J. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut Ramos García S. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut Antón García S. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut López Fernández P. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut Valle-Garay E. Biochemistry and Molecular Biology, Oviedo University Medical School, Oviedo, Spain aut Asensi V. Medicine Departments, Hospital Universitario Central de Asturias, Oviedo, Spain aut European Spine Journal Springer-Verlag 20(2011-08-01), 383-389 0940-6719 20<383 2011 20 586 https://doi.org/10.1007/s00586-011-1915-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1915-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paz Aparicio J. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Fernández Bances I. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- López-Anglada Fernández E. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Montes A. Biochemistry and Molecular Biology, Oviedo University Medical School, Oviedo, Spain aut NATIONALLICENCE 700 1- Paz Aparicio A. Anesthesiology and Critical Care, Hospital Universitario Central de Asturias, Oviedo, Spain aut NATIONALLICENCE 700 1- Pena Vázquez J. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Ramos García S. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Antón García S. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- López Fernández P. Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Valle-Garay E. Biochemistry and Molecular Biology, Oviedo University Medical School, Oviedo, Spain aut NATIONALLICENCE 700 1- Asensi V. Medicine Departments, Hospital Universitario Central de Asturias, Oviedo, Spain aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20(2011-08-01), 383-389 0940-6719 20<383 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer