caa a22 4500 445835036 CHVBK 20180627064141.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00586-011-1827-1 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1827-1 The effects of dynamic loading on the intervertebral disc [Elektronische Daten] [Samantha Chan, Stephen Ferguson, Benjamin Gantenbein-Ritter] Loading is important to maintain the balance of matrix turnover in the intervertebral disc (IVD). Daily cyclic diurnal assists in the transport of large soluble factors across the IVD and its surrounding circulation and applies direct and indirect stimulus to disc cells. Acute mechanical injury and accumulated overloading, however, could induce disc degeneration. Recently, there is more information available on how cyclic loading, especially axial compression and hydrostatic pressure, affects IVD cell biology. This review summarises recent studies on the response of the IVD and stem cells to applied cyclic compression and hydrostatic pressure. These studies investigate the possible role of loading in the initiation and progression of disc degeneration as well as quantifying a physiological loading condition for the study of disc degeneration biological therapy. Subsequently, a possible physiological/beneficial loading range is proposed. This physiological/beneficial loading could provide insight into how to design loading regimes in specific system for the testing of various biological therapies such as cell therapy, chemical therapy or tissue engineering constructs to achieve a better final outcome. In addition, the parameter space of ‘physiological' loading may also be an important factor for the differentiation of stem cells towards most ideally ‘discogenic' cells for tissue engineering purpose. Springer-Verlag, 2011 Intervertebral disc nationallicence Disc generation nationallicence Dynamic loading nationallicence Axial compression nationallicence Hydrostatic pressure nationallicence Mechanobiology nationallicence Chan Samantha ARTORG Center for Biomedical Engineering, Spine Research Center, Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland aut Ferguson Stephen ARTORG Center for Biomedical Engineering, Spine Research Center, Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland aut Gantenbein-Ritter Benjamin ARTORG Center for Biomedical Engineering, Spine Research Center, Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland aut European Spine Journal Springer-Verlag 20/11(2011-11-01), 1796-1812 0940-6719 20:11<1796 2011 20 586 https://doi.org/10.1007/s00586-011-1827-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1827-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chan Samantha ARTORG Center for Biomedical Engineering, Spine Research Center, Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland aut NATIONALLICENCE 700 1- Ferguson Stephen ARTORG Center for Biomedical Engineering, Spine Research Center, Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland aut NATIONALLICENCE 700 1- Gantenbein-Ritter Benjamin ARTORG Center for Biomedical Engineering, Spine Research Center, Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/11(2011-11-01), 1796-1812 0940-6719 20:11<1796 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 445835036 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer