caa a22 4500 445835109 CHVBK 20180317145328.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00586-011-1889-0 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1889-0 Prospective study of the effect of pedicle screw placement on development of the immature vertebra in an in vivo porcine model [Elektronische Daten] [Tamás Fekete, Frank Kleinstück, Anne Mannion, Zsolt Kendik, Dezső Jeszenszky] Introduction: There is increasing awareness of the need for pedicle screw constructs in the treatment of spinal deformities in very young children. However, the long-term effects of pedicle screws on the immature spine are still unclear. We used a porcine model to analyze the morphological changes of the spinal canal and vertebral body in response to the placement of pedicle screws. Methods: 13 newborn pigs were operated on. Each pig received a single pedicle screw at the L2 level. After a tenfold increase in body weight (7months later), the symmetry of the spinal canal and vertebral body was measured on CT scans of the investigational (L2) and control (L3) levels in terms of the angulations of the instrumented and non-instrumented halves of the vertebral body and spinal canal. Results: After 7months, the normalised vertebral body angle had reduced on the non-screw side and increased on the screw side, indicating asymmetry in vertebral body growth in the axial plane. The difference was significant (p=0.009). However, there was no significant difference between the screw and non-screw sides for the spinal canal angles at the L2 level at either the intraoperative or 7-month follow-up assessment (each p>0.05). Conclusions: Pedicle screws in the immature porcine spine have a significant effect on the development of the vertebral body. However, in the present study, no corresponding alteration of the morphology of the spinal canal was observed. Our results provide further support for the existing arguments in favour of pedicle screws when weighing up the many factors to be considered in creating a treatment plan for early onset scoliosis. Springer-Verlag, 2011 Pedicle screw nationallicence Porcine model nationallicence Vertebra development nationallicence Early onset spinal deformity (EOS, EOSD) nationallicence Fekete Tamás Spine Center, Schulthess Clinic, Zürich, Switzerland aut Kleinstück Frank Spine Center, Schulthess Clinic, Zürich, Switzerland aut Mannion Anne Spine Center Division, Department of Research and Development, Schulthess Clinic, Zürich, Switzerland aut Kendik Zsolt Department and Clinic of Surgery and Ophthalmology, Faculty of Veterinary Science, Szent Istvan University, Budapest, Hungary aut Jeszenszky Dezső Spine Center, Schulthess Clinic, Zürich, Switzerland aut European Spine Journal Springer-Verlag 20/11(2011-11-01), 1892-1898 0940-6719 20:11<1892 2011 20 586 https://doi.org/10.1007/s00586-011-1889-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1889-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fekete Tamás Spine Center, Schulthess Clinic, Zürich, Switzerland aut NATIONALLICENCE 700 1- Kleinstück Frank Spine Center, Schulthess Clinic, Zürich, Switzerland aut NATIONALLICENCE 700 1- Mannion Anne Spine Center Division, Department of Research and Development, Schulthess Clinic, Zürich, Switzerland aut NATIONALLICENCE 700 1- Kendik Zsolt Department and Clinic of Surgery and Ophthalmology, Faculty of Veterinary Science, Szent Istvan University, Budapest, Hungary aut NATIONALLICENCE 700 1- Jeszenszky Dezső Spine Center, Schulthess Clinic, Zürich, Switzerland aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/11(2011-11-01), 1892-1898 0940-6719 20:11<1892 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer