caa a22 4500 445835192 CHVBK 20180317145328.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00586-011-1830-6 doi (NATIONALLICENCE)springer-10.1007/s00586-011-1830-6 Porcine model of early onset scoliosis based on animal growth created with posterior mini-invasive spinal offset tethering A preliminary report [Elektronische Daten] [Th. Odent, Th. Cachon, B. Peultier, J. Gournay, E. Jolivet, C. Elie, H. Abdoul, E. Viguier] Several models of scoliosis were developed in the past 10years. In most of them, deformations are induced in old animals and required long time observation period and a chest wall ligation±resection. The purpose of the study was to create a scoliosis model with a size similar to an early onset scoliosis and an important growth potential without chest wall injuring. An original offset implant was fixed posteriorly and connected with a cable in seven (6+1 control) one-month-old Landrace pigs. The mean initial spinal length (T1-S1) was 25cm and the mean weight was 9kg. After 2months observation, spinal deformities were assessed with a three dimension stereographic analysis. In four animals, the cable was sectioned and the deformities followed-up for next 2months. No post-operative complication was observed. Mean weight growth was 10kg/month and mean spine lengthening (T1-S1) was 7cm/month. In 2months, we obtained structural scoliotic curves with vertebral and disk wedging which were maximal at the apex of the curve. Mean frontal and sagittal Cobb angles was 45°. Chest wall associated deformities were similar to those observed in scoliotic deformities and were correlated to spinal deformities (p=0.03). The cable section resulted in a partial curve regression influenced by disk elasticity and could probably be influenced by gravity loads (Decrease of the Cobb angle of 30% in the sagittal plane and 45% in the frontal plane). According to the results, the model creates a structural scoliosis and chest wall deformity that is similar to an early onset scoliosis. The spinal deformities were obtained quickly, and were consistent between animals in term of amount and characteristic. Springer-Verlag, 2011 Early onset scoliosis nationallicence Experimental scoliosis nationallicence Animal models nationallicence Growth modulation nationallicence Thorax growth nationallicence Odent Th Service de chirurgie orthopédique pédiatrique, Université Paris Descartes, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, 149, rue de Sèvres, 75015, Paris, France aut Cachon Th Université de Lyon, ICE 2007-03-135, VetAgro Sup, Campus vétérinaire, Lyon, France aut Peultier B. Medtronic Company, Tolochenaz, Switzerland aut Gournay J. Medtronic Company, Tolochenaz, Switzerland aut Jolivet E. Ecole Nationale Supérieure des Arts et Métiers, Paris Tech, Paris, France aut Elie C. Service de chirurgie orthopédique pédiatrique, Université Paris Descartes, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, 149, rue de Sèvres, 75015, Paris, France aut Abdoul H. Service de chirurgie orthopédique pédiatrique, Université Paris Descartes, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, 149, rue de Sèvres, 75015, Paris, France aut Viguier E. Université de Lyon, ICE 2007-03-135, VetAgro Sup, Campus vétérinaire, Lyon, France aut European Spine Journal Springer-Verlag 20/11(2011-11-01), 1869-1876 0940-6719 20:11<1869 2011 20 586 https://doi.org/10.1007/s00586-011-1830-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00586-011-1830-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Odent Th Service de chirurgie orthopédique pédiatrique, Université Paris Descartes, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, 149, rue de Sèvres, 75015, Paris, France aut NATIONALLICENCE 700 1- Cachon Th Université de Lyon, ICE 2007-03-135, VetAgro Sup, Campus vétérinaire, Lyon, France aut NATIONALLICENCE 700 1- Peultier B. Medtronic Company, Tolochenaz, Switzerland aut NATIONALLICENCE 700 1- Gournay J. Medtronic Company, Tolochenaz, Switzerland aut NATIONALLICENCE 700 1- Jolivet E. Ecole Nationale Supérieure des Arts et Métiers, Paris Tech, Paris, France aut NATIONALLICENCE 700 1- Elie C. Service de chirurgie orthopédique pédiatrique, Université Paris Descartes, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, 149, rue de Sèvres, 75015, Paris, France aut NATIONALLICENCE 700 1- Abdoul H. Service de chirurgie orthopédique pédiatrique, Université Paris Descartes, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, 149, rue de Sèvres, 75015, Paris, France aut NATIONALLICENCE 700 1- Viguier E. Université de Lyon, ICE 2007-03-135, VetAgro Sup, Campus vétérinaire, Lyon, France aut NATIONALLICENCE 773 0- European Spine Journal Springer-Verlag 20/11(2011-11-01), 1869-1876 0940-6719 20:11<1869 2011 20 586 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer