caa a22 4500 445840447 CHVBK 20180317145342.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00709-010-0205-x doi (NATIONALLICENCE)springer-10.1007/s00709-010-0205-x Variations on theme: spindle assembly in diverse cells [Elektronische Daten] [Patricia Wadsworth, Wei-Lih Lee, Takashi Murata, Tobias Baskin] The mitotic spindle faithfully separates the genetic material, and has been reverently observed for well over a century. Across eukaryotes, while the mechanisms for moving chromosomes seem quite conserved, mechanisms for assembling the spindle often seem distinct. Two major pathways for spindle assembly are known, one based on centrosomes and the other based on chromatin, and these pathways are usually considered to be fundamentally different. We review observations of spindle assembly in animals, fungi, and plants, and argue that microtubule assembly at a particular location, centrosomes, or chromatin, reflects contingent, cell-type specific factors, rather than reflecting a fundamental distinction in the process of spindle building. We hypothesize that the essential process for spindle assembly is the motor-driven organization of microtubules that accumulate in the form of dense bundles at or near the chromosomes. Springer-Verlag, 2010 Centrosomes nationallicence Mitosis nationallicence Plant spindle nationallicence Vertebrate spindle nationallicence Yeast spindle nationallicence Wadsworth Patricia Department of Biology, Morrill Science Center, University of Massachusetts, 01003, Amherst, MA, USA aut Lee Wei-Lih Department of Biology, Morrill Science Center, University of Massachusetts, 01003, Amherst, MA, USA aut Murata Takashi National Institute for Basic Biology, Myodaiji-cho, Okazaki, Aichi, Japan aut Baskin Tobias Department of Biology, Morrill Science Center, University of Massachusetts, 01003, Amherst, MA, USA aut Protoplasma Springer Vienna 248/3(2011-07-01), 439-446 0033-183X 248:3<439 2011 248 709 https://doi.org/10.1007/s00709-010-0205-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00709-010-0205-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wadsworth Patricia Department of Biology, Morrill Science Center, University of Massachusetts, 01003, Amherst, MA, USA aut NATIONALLICENCE 700 1- Lee Wei-Lih Department of Biology, Morrill Science Center, University of Massachusetts, 01003, Amherst, MA, USA aut NATIONALLICENCE 700 1- Murata Takashi National Institute for Basic Biology, Myodaiji-cho, Okazaki, Aichi, Japan aut NATIONALLICENCE 700 1- Baskin Tobias Department of Biology, Morrill Science Center, University of Massachusetts, 01003, Amherst, MA, USA aut NATIONALLICENCE 773 0- Protoplasma Springer Vienna 248/3(2011-07-01), 439-446 0033-183X 248:3<439 2011 248 709 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer