caa a22 4500 445842717 CHVBK 20180317145349.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s11047-010-9216-y doi (NATIONALLICENCE)springer-10.1007/s11047-010-9216-y A simple mass-action model for the eukaryotic heat shock response and its mathematical validation [Elektronische Daten] [Ion Petre, Andrzej Mizera, Claire Hyder, Annika Meinander, Andrey Mikhailov, Richard Morimoto, Lea Sistonen, John Eriksson, Ralph-Johan Back] The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides a useful foundation for modeling strategies of more complex cellular processes. Springer Science+Business Media B.V., 2010 Heat shock response nationallicence Heat shock protein nationallicence Heat shock factor nationallicence Heat shock element nationallicence Mathematical model nationallicence Validation nationallicence Regulatory network nationallicence Petre Ion Department of Information Technologies, Åbo Akademi University, 20520, Turku, Finland aut Mizera Andrzej Department of Information Technologies, Åbo Akademi University, 20520, Turku, Finland aut Hyder Claire Turku Centre for Biotechnology, Turku, Finland aut Meinander Annika Turku Centre for Biotechnology, Turku, Finland aut Mikhailov Andrey Turku Centre for Biotechnology, Turku, Finland aut Morimoto Richard Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, 60208, Evanston, IL, USA aut Sistonen Lea Turku Centre for Biotechnology, Turku, Finland aut Eriksson John Turku Centre for Biotechnology, Turku, Finland aut Back Ralph-Johan Department of Information Technologies, Åbo Akademi University, 20520, Turku, Finland aut Natural Computing Springer Netherlands 10/1(2011-03-01), 595-612 1567-7818 10:1<595 2011 10 11047 https://doi.org/10.1007/s11047-010-9216-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11047-010-9216-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Petre Ion Department of Information Technologies, Åbo Akademi University, 20520, Turku, Finland aut NATIONALLICENCE 700 1- Mizera Andrzej Department of Information Technologies, Åbo Akademi University, 20520, Turku, Finland aut NATIONALLICENCE 700 1- Hyder Claire Turku Centre for Biotechnology, Turku, Finland aut NATIONALLICENCE 700 1- Meinander Annika Turku Centre for Biotechnology, Turku, Finland aut NATIONALLICENCE 700 1- Mikhailov Andrey Turku Centre for Biotechnology, Turku, Finland aut NATIONALLICENCE 700 1- Morimoto Richard Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, 60208, Evanston, IL, USA aut NATIONALLICENCE 700 1- Sistonen Lea Turku Centre for Biotechnology, Turku, Finland aut NATIONALLICENCE 700 1- Eriksson John Turku Centre for Biotechnology, Turku, Finland aut NATIONALLICENCE 700 1- Back Ralph-Johan Department of Information Technologies, Åbo Akademi University, 20520, Turku, Finland aut NATIONALLICENCE 773 0- Natural Computing Springer Netherlands 10/1(2011-03-01), 595-612 1567-7818 10:1<595 2011 10 11047 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer