caa a22 4500 445843071 CHVBK 20180317145350.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s11047-010-9199-8 doi (NATIONALLICENCE)springer-10.1007/s11047-010-9199-8 Algorithmic applications of XPCR [Elektronische Daten] [Giuditta Franco, Vincenzo Manca] An emerging trend in DNA computing consists of the algorithmic analysis of new molecular biology technologies, and in general of more effective tools to tackle computational biology problems. An algorithmic understanding of the interaction between DNA molecules becomes the focus of some research which was initially addressed to solve mathematical problems by processing data within biomolecules. In this paper a novel mechanism of DNA recombination is discussed, that turned out to be a good implementation key to develop new procedures for DNA manipulation (Franco etal., DNA extraction by cross pairing PCR, 2005; Franco etal., DNA recombination by XPCR, 2006; Manca and Franco, Math Biosci 211:282-298, 2008). It is called XPCR as it is a variant of the polymerase chain reaction (PCR), which was a revolution in molecular biology as a technique for cyclic amplification of DNA segments. A few DNA algorithms are proposed, that were experimentally proven in different contexts, such as, mutagenesis (Franco, Biomolecular computing—combinatorial algorithms and laboratory experiments, 2006), multiple concatenation, gene driven DNA extraction (Franco etal., DNA extraction by cross pairing PCR, 2005), and generation of DNA libraries (Franco etal., DNA recombination by XPCR, 2006), and some related ongoing work is outlined. Springer Science+Business Media B.V., 2010 Algorithmic analysis nationallicence DNA extraction nationallicence DNA mutagenesis nationallicence DNA recombination nationallicence PCR nationallicence Splicing nationallicence Franco Giuditta Department of Computer Science, University of Verona, Strada Le Grazie 15, 37134, Verona, Italy aut Manca Vincenzo Department of Computer Science, University of Verona, Strada Le Grazie 15, 37134, Verona, Italy aut Natural Computing Springer Netherlands 10/2(2011-06-01), 805-819 1567-7818 10:2<805 2011 10 11047 https://doi.org/10.1007/s11047-010-9199-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11047-010-9199-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Franco Giuditta Department of Computer Science, University of Verona, Strada Le Grazie 15, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Manca Vincenzo Department of Computer Science, University of Verona, Strada Le Grazie 15, 37134, Verona, Italy aut NATIONALLICENCE 773 0- Natural Computing Springer Netherlands 10/2(2011-06-01), 805-819 1567-7818 10:2<805 2011 10 11047 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer