caa a22 4500 445844795 CHVBK 20180317145355.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10709-010-9482-8 doi (NATIONALLICENCE)springer-10.1007/s10709-010-9482-8 Developing transgenic Anopheles mosquitoes for the sterile insect technique [Elektronische Daten] [Tony Nolan, Philippos Papathanos, Nikolai Windbichler, Kalle Magnusson, Jason Benton, Flaminia Catteruccia, Andrea Crisanti] In the last 10years the availability of the genome sequence of Anopheles gambiae and the development of a transgenic technology for several species of Anopheles mosquitoes have, in combination, helped in enabling us to gain several insights into the biology of these mosquitoes that is relevant to their capacity as vectors of the malaria parasite. While this information is anticipated to inform many novel vector control strategies, the technique most likely to benefit in the near future from the availability of a reliable transgenic technology is the sterile insect technique (SIT), which relies on releasing large numbers of sterile insects to compete for mates in the wild, leading to population suppression. Although SIT has been proven to work reliably for many insects, the construction of suitable strains, and induction of sterility, has until now been a laborious process, combining classical genetics with radiation-induced sterility. Using transgenesis to create strains of Anopheles suitable for SIT could potentially offer several advantages over current approaches, in that the basic design of transgenic constructs designed for other insects should be rapidly transferable to mosquitoes, and induction of sterility as a product of the transgenic modification could obviate the requirement for radiation and its associated deleterious effects. In this paper the progress of different transgenic approaches in constructing tools for SIT will be reviewed. Springer Science+Business Media B.V., 2010 Anopheles nationallicence Transgenic nationallicence Mosquitoes nationallicence Sterile insect technique nationallicence Malaria nationallicence Dominant lethality nationallicence Nolan Tony Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut Papathanos Philippos Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut Windbichler Nikolai Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut Magnusson Kalle Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut Benton Jason Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut Catteruccia Flaminia Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut Crisanti Andrea Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut Genetica Springer Netherlands 139/1(2011-01-01), 33-39 0016-6707 139:1<33 2011 139 10709 https://doi.org/10.1007/s10709-010-9482-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10709-010-9482-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nolan Tony Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut NATIONALLICENCE 700 1- Papathanos Philippos Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut NATIONALLICENCE 700 1- Windbichler Nikolai Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut NATIONALLICENCE 700 1- Magnusson Kalle Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut NATIONALLICENCE 700 1- Benton Jason Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut NATIONALLICENCE 700 1- Catteruccia Flaminia Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut NATIONALLICENCE 700 1- Crisanti Andrea Faculty of Life Sciences, Imperial College London, SW7 2AZ, London, UK aut NATIONALLICENCE 773 0- Genetica Springer Netherlands 139/1(2011-01-01), 33-39 0016-6707 139:1<33 2011 139 10709 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer