caa a22 4500 445845988 CHVBK 20180317145359.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10709-010-9537-x doi (NATIONALLICENCE)springer-10.1007/s10709-010-9537-x Inactivation dates of the human and guinea pig vitamin C genes [Elektronische Daten] [Marc Lachapelle, Guy Drouin] The capacity to biosynthesize ascorbic acid has been lost in a number of species including primates, guinea pigs, teleost fishes, bats, and birds. This inability results from mutations in the GLO gene coding for L-gulono-γ-lactone oxidase, the enzyme responsible for catalyzing the last step in the vitamin C biosynthetic pathway. We analyzed available primate and rodent GLO gene sequences to determine their evolutionary history. We used a method based on sequence comparisons of lineages with and without functional GLO genes to calculate inactivation dates of 61 and 14 MYA for the primate and guinea pig genes, respectively. These estimates are consistent with previous phylogeny-based estimates. An analysis of transposable element distribution in the primate and rodent GLO sequences did not reveal conclusive evidence that illegitimate recombination between repeats has contributed to the loss of exons in the primate and guinea pig genes. Springer Science+Business Media B.V., 2010 Vitamin C nationallicence L-gulono-γ-lactone oxidase nationallicence GLO gene nationallicence Unitary pseudogene nationallicence Human nationallicence Guinea pig nationallicence Lachapelle Marc Département de biologie et Centre de recherche avancée en génomique environnementale, Université d'Ottawa, 30 Marie Curie, K1N 6N5, Ottawa, ON, Canada aut Drouin Guy Département de biologie et Centre de recherche avancée en génomique environnementale, Université d'Ottawa, 30 Marie Curie, K1N 6N5, Ottawa, ON, Canada aut Genetica Springer Netherlands 139/2(2011-02-01), 199-207 0016-6707 139:2<199 2011 139 10709 https://doi.org/10.1007/s10709-010-9537-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10709-010-9537-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lachapelle Marc Département de biologie et Centre de recherche avancée en génomique environnementale, Université d'Ottawa, 30 Marie Curie, K1N 6N5, Ottawa, ON, Canada aut NATIONALLICENCE 700 1- Drouin Guy Département de biologie et Centre de recherche avancée en génomique environnementale, Université d'Ottawa, 30 Marie Curie, K1N 6N5, Ottawa, ON, Canada aut NATIONALLICENCE 773 0- Genetica Springer Netherlands 139/2(2011-02-01), 199-207 0016-6707 139:2<199 2011 139 10709 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer