caa a22 4500 445846046 CHVBK 20180317145359.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10709-010-9534-0 doi (NATIONALLICENCE)springer-10.1007/s10709-010-9534-0 Evolution of subterminal satellite (StSat) repeats in hominids [Elektronische Daten] [Akihiko Koga, Morihiro Notohara, Hirohisa Hirai] Subterminal satellite (StSat) repeats, consisting of 32-bp-long AT-rich units (GATATTTCCATGTT(T/C)ATACAGATAGCGGTGTA), were first found in chimpanzee and gorilla (African great apes) as one of the major components of heterochromatic regions located proximal to telomeres of chromosomes. StSat repeats have not been found in orangutan (Asian great ape) or human. This patchy distribution among species suggested that the StSat repeats were present in the common ancestor of African great apes and subsequently lost in the lineage leading to human. An alternative explanation is that the StSat repeats in chimpanzee and gorilla have different origins and the repeats did not occur in human. The purpose of the present study was quantitative evaluation of the above alternative possibilities by analyzing the nucleotide variation contained in the repeats. We collected large numbers of sequences of repeat units from genome sequence databases of chimpanzee and gorilla, and also bonobo (an African great ape phylogenetically closer to chimpanzee). We then compared the base composition of the repeat units among the 3 species, and found statistically significant similarities in the base composition. These results support the view that the StSat repeats had already formed multiple arrays in the common ancestor of African great apes. It is thus suggested that humans lost StSat repeats which had once grown to multiple arrays. Springer Science+Business Media B.V., 2010 Tandem repeats nationallicence Heterochromatin nationallicence Subterminal region nationallicence RCRO nationallicence Hominids nationallicence Human nationallicence Koga Akihiko Primate Research Institute, Kyoto University, 464-8506, Inuyama City, Japan aut Notohara Morihiro Graduate School of Natural Sciences, Nagoya City University, 467-8501, Nagoya, Japan aut Hirai Hirohisa Primate Research Institute, Kyoto University, 464-8506, Inuyama City, Japan aut Genetica Springer Netherlands 139/2(2011-02-01), 167-175 0016-6707 139:2<167 2011 139 10709 https://doi.org/10.1007/s10709-010-9534-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10709-010-9534-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koga Akihiko Primate Research Institute, Kyoto University, 464-8506, Inuyama City, Japan aut NATIONALLICENCE 700 1- Notohara Morihiro Graduate School of Natural Sciences, Nagoya City University, 467-8501, Nagoya, Japan aut NATIONALLICENCE 700 1- Hirai Hirohisa Primate Research Institute, Kyoto University, 464-8506, Inuyama City, Japan aut NATIONALLICENCE 773 0- Genetica Springer Netherlands 139/2(2011-02-01), 167-175 0016-6707 139:2<167 2011 139 10709 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer