caa a22 4500 445847530 CHVBK 20180317145403.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10548-011-0198-6 doi (NATIONALLICENCE)springer-10.1007/s10548-011-0198-6 Age-Related Changes in the Thickness of Cortical Zones in Humans [Elektronische Daten] [Scott McGinnis, Michael Brickhouse, Belen Pascual, Bradford Dickerson] Structural neuroimaging studies have demonstrated that all regions of the cortex are not affected equally by aging, with frontal regions appearing especially susceptible to atrophy. The "last in, first out” hypothesis posits that aging is, in a sense, the inverse of development: late-maturing regions of the brain are preferentially vulnerable to age-related loss of structural integrity. We tested this hypothesis by analyzing age-related changes in regional cortical thickness via three methods: (1) an exploratory linear regression of cortical thickness and age across the entire cortical mantle (2) an analysis of age-related differences in the thickness of zones of cortex defined by functional/cytoarchitectural affiliation (including primary sensory/motor, unimodal association, heteromodal association, and paralimbic zones), and (3) an analysis of age-related differences in the thickness of regions of cortex defined by surface area expansion in the period between birth and early adulthood. Subjects were grouped as young (aged 18-29, n=138), middle-aged (aged 30-59, n=80), young-old (aged 60-79, n=60), and old-old (aged 80+, n=38). Thinning of the cortex between young and middle-aged adults was greatest in heteromodal association cortex and regions of high postnatal surface area expansion. In contrast, thinning in old-old age was greatest in primary sensory/motor cortices and regions of low postnatal surface area expansion. In sum, these results lead us to propose a sequential "developmental-sensory” model of aging, in which developmental factors influence cortical vulnerability relatively early in the aging process, whereas later—in more advanced stages of aging—factors specific to primary sensory and motor cortices confer vulnerability. This model offers explicitly testable hypotheses and suggests the possibility that normal aging may potentially allow for multiple opportunities for intervention to promote the structural integrity of the cerebral cortex. Springer Science+Business Media, LLC, 2011 Magnetic resonance imaging nationallicence Morphometry nationallicence Cortex nationallicence Aging nationallicence McGinnis Scott Frontotemporal Dementia Unit, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA aut Brickhouse Michael Frontotemporal Dementia Unit, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA aut Pascual Belen Frontotemporal Dementia Unit, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA aut Dickerson Bradford Frontotemporal Dementia Unit, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA aut Brain Topography Springer US; http://www.springer-ny.com 24/3-4(2011-10-01), 279-291 0896-0267 24:3-4<279 2011 24 10548 https://doi.org/10.1007/s10548-011-0198-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10548-011-0198-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McGinnis Scott Frontotemporal Dementia Unit, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Brickhouse Michael Frontotemporal Dementia Unit, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Pascual Belen Frontotemporal Dementia Unit, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Dickerson Bradford Frontotemporal Dementia Unit, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 773 0- Brain Topography Springer US; http://www.springer-ny.com 24/3-4(2011-10-01), 279-291 0896-0267 24:3-4<279 2011 24 10548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer