caa a22 4500 445847549 CHVBK 20180317145403.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10548-011-0183-0 doi (NATIONALLICENCE)springer-10.1007/s10548-011-0183-0 Central Adaptations to Repetitive Grasping in Healthy Aging [Elektronische Daten] [Michael Falvo, Erik Sirevaag, John Rohrbaugh, Gammon Earhart] Augmented cortical activity during repetitive grasping mitigates repetition-related decrease in cortical efficiency in young adults. It is unclear if similar processes occur with healthy aging. We recorded movement-related cortical potentials (MRCP) during 150 repetitive handgrip contractions at 70% of maximal voluntary contraction (MVC) in healthy young (n=10) and old (n=10) adults. Repetitions were grouped into two Blocks (Block 1 and 2: repetitions 1-60 and 91-150, respectively) and analyzed separately to assess the effects of aging and block. EMG of the flexor digitorum superficialis and handgrip force were also recorded. No changes in EMG or MVC were observed across blocks for either group. Significant interactions (P<0.05) were observed for MRCPs recorded from mesial (FCz, Cz, CPz) and motor (C1, C3, Cz) electrode sites, with younger adults demonstrating significant increases in MRCP amplitude. Focal MRCP activity in response to repetitive grasping resulted in minimal changes (i.e. Block 1 versus Block 2) in older adults. Central adaptive processes change across the lifespan, showing increasingly less focal activation in older adults during repetitive grasping. Our findings are consistent with previous paradigms demonstrating more diffuse cortical activation during motor tasks in older adults. Springer Science+Business Media, LLC, 2011 Movement-related cortical potential nationallicence Bereitschaftspotential nationallicence Central adaptation nationallicence Repetitive voluntary contraction nationallicence Aging nationallicence Falvo Michael War Related Illness and Injury Study Center, Department of Veterans Affairs, VA New Jersey Health Care System, 385 Tremont Ave, 07108, East Orange, NJ, USA aut Sirevaag Erik Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA aut Rohrbaugh John Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA aut Earhart Gammon Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA aut Brain Topography Springer US; http://www.springer-ny.com 24/3-4(2011-10-01), 292-301 0896-0267 24:3-4<292 2011 24 10548 https://doi.org/10.1007/s10548-011-0183-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10548-011-0183-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Falvo Michael War Related Illness and Injury Study Center, Department of Veterans Affairs, VA New Jersey Health Care System, 385 Tremont Ave, 07108, East Orange, NJ, USA aut NATIONALLICENCE 700 1- Sirevaag Erik Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Rohrbaugh John Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Earhart Gammon Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 773 0- Brain Topography Springer US; http://www.springer-ny.com 24/3-4(2011-10-01), 292-301 0896-0267 24:3-4<292 2011 24 10548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer