caa a22 4500 445847638 CHVBK 20180317145403.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10548-011-0195-9 doi (NATIONALLICENCE)springer-10.1007/s10548-011-0195-9 Structural and Functional Imaging Correlates of Cognitive and Brain Reserve Hypotheses in Healthy and Pathological Aging [Elektronische Daten] [David Bartrés-Faz, Eider Arenaza-Urquijo] In the field of ageing and dementia, brain- or cognitive reserve refers to the capacity of the brain to manage pathology or age-related changes thereby minimizing clinical manifestations. The brain reserve capacity (BRC) hypothesis argues that this capacity derives from an individual's unique neural profile (e.g., cell count, synaptic connections, brain volume, etc.). Complimentarily, the cognitive reserve (CR) hypothesis emphasizes inter-individual differences in the effective recruitment of neural networks and cognitive processes to compensate for age-related effects or pathology. Despite an abundance of research, there is scarce literature attempting to synthesize the BRC the CR models. In this paper, we will review important aging and dementia studies using structural and functional neuroimaging techniques to investigate and attempt to assimilate both reserve hypotheses. The possibility to conceptualize reserve as reflecting indexes of brain plasticity will be proposed and novel data suggesting an intimate and complex correspondence between active and passive components of reserve will be presented. Springer Science+Business Media, LLC, 2011 Aging nationallicence Dementia nationallicence Brain reserve nationallicence Cognitive reserve nationallicence Neuroplasticity nationallicence MRI nationallicence Functional MRI nationallicence Cognition nationallicence Brain networks nationallicence Compensation nationallicence Bartrés-Faz David Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, Casanova 143, 08036, Barcelona, Spain aut Arenaza-Urquijo Eider Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, Casanova 143, 08036, Barcelona, Spain aut Brain Topography Springer US; http://www.springer-ny.com 24/3-4(2011-10-01), 340-357 0896-0267 24:3-4<340 2011 24 10548 https://doi.org/10.1007/s10548-011-0195-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10548-011-0195-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bartrés-Faz David Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, Casanova 143, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Arenaza-Urquijo Eider Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, Casanova 143, 08036, Barcelona, Spain aut NATIONALLICENCE 773 0- Brain Topography Springer US; http://www.springer-ny.com 24/3-4(2011-10-01), 340-357 0896-0267 24:3-4<340 2011 24 10548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer