caa a22 4500 445847654 CHVBK 20180317145404.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10548-011-0170-5 doi (NATIONALLICENCE)springer-10.1007/s10548-011-0170-5 Hippocampal Proton MR Spectroscopy in Early Alzheimer's Disease and Mild Cognitive Impairment [Elektronische Daten] [Catherine Foy, Eileen Daly, Amanda Glover, Ruth O'Gorman, Andrew Simmons, Declan Murphy, Simon Lovestone] Proton magnetic resonance spectroscopy (1H-MRS) studies have previously reported reduced brain N-acetyl aspartate (NAA) and increased myo-inositol (mI) in people with established Alzheimer's disease (AD). The earliest structure affected by AD is the hippocampus but relatively few studies have examined its neuronal integrity by MRS in AD and fewer still in people with amnestic mild cognitive impairment (MCI). We measured the hippocampal concentration of NAA, mI, choline (Cho) and creatine+phosphocreatine (Cr+PCr) in 39 patients with AD, 21 subjects with MCI and 38 age matched healthy elderly controls. Patients with AD had a significantly lower hippocampal [NAA] than controls, with subjects with MCI intermediate between the other two groups. [NAA] was positively correlated with memory in the impaired groups. Using mean hippocampal [NAA] and [Cr+PCr] we correctly classified 72% of people with AD, and 75% of controls. Reductions in [NAA] can be detected in the hippocampi of subjects with MCI and hippocampal [NAA] and [Cr+PCr] can distinguish between mild AD and normal elderly controls. Springer Science+Business Media, LLC, 2011 Alzheimer's disease nationallicence MRS nationallicence Diagnosis nationallicence Post-mortem nationallicence Algorithm nationallicence Foy Catherine Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King's College London, London, UK aut Daly Eileen Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King's College London, London, UK aut Glover Amanda National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health, Institute of Psychiatry, King's College London, London, UK aut O'Gorman Ruth Department of Neuroimaging, Institute of Psychiatry, King's College London, De Crespigny Park, SE5 8AF, London, UK aut Simmons Andrew Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King's College London, London, UK aut Murphy Declan National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health, Institute of Psychiatry, King's College London, London, UK aut Lovestone Simon Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King's College London, London, UK aut Brain Topography Springer US; http://www.springer-ny.com 24/3-4(2011-10-01), 316-322 0896-0267 24:3-4<316 2011 24 10548 https://doi.org/10.1007/s10548-011-0170-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10548-011-0170-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Foy Catherine Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King's College London, London, UK aut NATIONALLICENCE 700 1- Daly Eileen Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King's College London, London, UK aut NATIONALLICENCE 700 1- Glover Amanda National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health, Institute of Psychiatry, King's College London, London, UK aut NATIONALLICENCE 700 1- O'Gorman Ruth Department of Neuroimaging, Institute of Psychiatry, King's College London, De Crespigny Park, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Simmons Andrew Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King's College London, London, UK aut NATIONALLICENCE 700 1- Murphy Declan National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health, Institute of Psychiatry, King's College London, London, UK aut NATIONALLICENCE 700 1- Lovestone Simon Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King's College London, London, UK aut NATIONALLICENCE 773 0- Brain Topography Springer US; http://www.springer-ny.com 24/3-4(2011-10-01), 316-322 0896-0267 24:3-4<316 2011 24 10548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer